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Access type: UnknownSubject: search.filters.subject.Mesua ferrea

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    Bioactive compounds from Mesua ferrea stems
    (2015-01-01)
    Keawsa-Ard, Sukanya
    ;
    Liawruangrath, Boonsom
    ;
    Kongtaweelert, Samart
    The chemical constituents and biological activities of Mesua ferrea Linn. were studied. The stems of M. ferrea were extracted with hexane, dichloromethane and methanol, respectively. The methanol extract exhibited the highest antibacterial activity against Escherichia coli with the MIC value of 31.25 μg/mL. The methanol extract and the dichloromethane extract exhibited the highest activity against Staphylococcus aureus with the MIC values of 31.25 μg/mL. The dichloromethane extract exhibited anticancer activities against KB-oral, MCF-7 and NCI-H187 cell lines with the IC<inf>50</inf>values of 18.01, 28.83 and 18.42 μg/mL, respectively. Friedelin, the mixture of α-amyrin and β-amyrin, lupeol and β-sitosterol were isolated from the active dichloromethane extract of the stems. Friedelin, the mixture of α-amyrin and β-amyrin, lupeol and β-sitosterol showed the antibacterial activity against E. coli with the MIC values of 250, 250, 250 and 1000 μg/mL, respectively. They also showed antibacterial activity against S. aureus with the MIC values of 250, 250, 500 and 1000 μg/mL, respectively. The mixture of α-amyrin and β-amyrin exhibited anticancer activity against MCF-7 cell line with the IC<inf>50</inf>value 28.45 μg/mL and lupeol exhibited anticancer activities against KB, MCF-7 and NCI-H187 cell lines with the IC<inf>50</inf>values of 30.12, 34.25 and 21.56 μg/mL, respectively. All the extracts and the isolated compounds were non-cytotoxic to Vero cells.
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    Antioxidant, antibacterial, anticancer activities and chemical constituents of the essential oil from Mesua ferrea leaves
    (2012-01-01)
    Keawsa-Ard, Sukanya
    ;
    Kongtaweelert, Samart
    Essential oil from leaves of Mesua ferrea L. was isolated by hydrodistillation and analyzed by means of GC and GC-MS. The yield of obtained essential oil was at 0.064% and it was appearred as yellow liquid. Thirty-five constituents were identified, constituting 81.4% of the total volatile components. The major constituents were trans-caryophyllene (30.9%), β-caryophyllene oxide (17.9%), α-humulene (6.0%), δ-cadinene (4.1%), γ-muurolene (3.5%), γ-cadinene (2.3%), β-selinene (1.9%), germacrene D (1.8%) and β-bisabolene (1.6%). Antioxidant activity of the essential oi l was evaluated by using the DPPH (1,1-diphenyl-2-picrylhydrazyl) radicals scavenging assay. The essential oil showed antioxidant activity with the IC<inf>50</inf> of 31.67 mg/mL. In addition, the essential oil exhibited significant antibacterial activity against Escherichia coli and Staphylococcus aureus with the MIC values of 250 and 125 mg/mL, respectively. This oil also exhibited anticancer activities against KB, MCF-7 and NCI-H187 cell lines with the IC<inf>50</inf> values of 24.02, 16.19, and 20.32 μg/mL, respectively, but it was non-cytotoxic to Vero cell line.