Search Results

Now showing 1 - 4 of 4

Some of the metrics are blocked by your
consent settings
Antimalarial and antimicrobial substances from the endophytic fungus Chaetomium globosum BCC71876
(2026-01-01)
Bunbamrung, Nantiya
;
Intaraudom, Chakapong
;
Dramae, Aibrohim
;
Boonyuen, Nattawut
;
Choowong, Wilunda
Three previously undescribed compounds including 2′,3′-dihydroxy-4,5′,4″-trimethoxy-p-terphenyl (1), 5-methoxyhydroperoxycochliodinol (2), and 5-(3′,3′-dimethylallyl)indole-3-oxoacetic acid (17), along with fifteen known compounds (3–16 and 18), were isolated from the endophytic fungus, Chaetomium globosum BCC71876. The chemical structures were determined by NMR spectral information as well as the comparison with those closely related compounds reported in the literature. The compounds isolated were evaluated for biological properties including antimalarial, anti-TB, anti-plant pathogenic fungal, antibacterial, and cytotoxicity. The isolated compounds exhibited a wide range of biological activities against the tested cell lines and showed very low cytotoxicity against both cancerous (MCF-7 and NCI-H187) and non-cancerous (Vero) cells, except for compounds 5, 10, 11, 17, and 18 (IC<inf>50</inf> 0.47 − 114.8 µM). Cochliodinol (5) had the strongest antimalarial activity (IC<inf>50</inf> 4.39 µM), whereas chaetomugilin J (11) showed the strongest anti-TB activity (MIC 3.13 µg/mL).
Some of the metrics are blocked by your
consent settings
Antimalarial and antimicrobial substances isolated from the endophytic actinomycete, Streptomyces aculeolatus MS1-6
(2023-03-01)
Kuncharoen, Nattakorn
;
Bunbamrung, Nantiya
;
Intaraudom, Chakapong
;
Choowong, Wilunda
;
Thawai, Chitti
Seven undescribed compounds, including four naphthoquinone terpenoids (aculeolatins A – D), one rare 2-nitropyrrole terpenoid (nitropyrrolin F), and two hydroxamate siderophores (aculeolamides A and B) and one further undescribed compound (2,5,7-trihydroxy-3,6-dimethylnaphthalene-1,4-dione), together with eleven known compounds (arromycin, phenaziterpene A, nitropyrrolin A, heronapyrroles A and B, salaceyin A, 5,7-dihydroxy-2-isopropylchromone, 1-hydroxyphenazine, 1-methoxyphenazine, 1-acetyl-β-carboline, and N-(2-phenylethyl) acetamide), were isolated from the cultures of the endophytic Streptomyces aculeolatus MS1-6. The structures of the isolated compounds were determined using NMR spectroscopy and corroborated using chemical modification. These compounds exhibited a broad spectrum of biological activities, including antimalarial (IC<inf>50</inf> 6.03–9.84 μg/mL), antitubercular (MIC 3.13–6.25 μg/mL), anti-plant pathogenic fungal (MIC 25.0–50.0 μg/mL), and antibacterial (MIC 3.03–50 μg/mL) activities; however, they displayed unremarkable cytotoxicity against cancerous (MCF-7 and NCI–H187) and non-cancerous (Vero) cell lines.
1
Some of the metrics are blocked by your
consent settings
Bioactive Dimeric Tetrahydroxanthones with 2,2′- And 4,4′-Axial Linkages from the Entomopathogenic FungusAschersonia confluens
(2021-04-23)
Sadorn, Karoon
;
Saepua, Siriporn
;
Boonyuen, Nattawut
;
Choowong, Wilunda
;
Rachtawee, Pranee
Thirteen tetrahydroxanthone dimers,atrop-ascherxanthone A (1), ascherxanthones C-G (2-6), and confluxanthones A-G (7-13), were isolated from the entomopathogenic fungusAschersonia confluensBCC53152. The chemical structures were determined based on analysis of NMR spectroscopic and mass spectrometric data. The absolute configurations of compounds1and7were confirmed by single-crystal X-ray diffraction experiments, while the configurations of other compounds were assigned based upon evidence from NOESY and NOEDIFF experiments, modified Mosher’s method, and ECD spectroscopic data together with biogenetic considerations. Compounds1,3-5,7-11, and13showed antimalarial activity againstPlasmodium falciparum(K1, multidrug-resistant strain) (IC<inf>50</inf>0.6-6.1 μM), antitubercular activity againstMycobacterium tuberculosisH37Ra (MIC 6.3-25.0 μg/mL), and cytotoxicity against NCI-H187 (IC<inf>50</inf>0.5-3.5 μM) and Vero (IC<inf>50</inf>0.9-6.1 μM) cells. All tested compounds except for compound9exhibited cytotoxicity against KB cells (IC<inf>50</inf>1.3-9.7 μM).
Some of the metrics are blocked by your
consent settings
Chromanones and aryl glucoside analogs from the entomopathogenic fungus Aschersonia confluens BCC53152
(2020-07-01)
Sadorn, Karoon
;
Saepua, Siriporn
;
Punyain, Wikorn
;
Saortep, Wacharee
;
Choowong, Wilunda
Six new compounds [ascherlactones A (1) and B (2), ascherchromanone A (3), phenethyl 4′-O-methylglucoside (8), 4′-O-methylpleoside (10), and 4′-O-methyltorachrysone 8-O-glucoside (11)] and one naturally new compound [4′-O-methyl-β-D-benzylglucoside (9)] together with fourteen known compounds, including paecilodepsipeptides A (5), B (7), and D (4), conoideocrellide A (6), eugenin (12), 5-hydroxy-2,3-dimethyl-7-methoxychromone (13), (S)-1-phenyl-1,2-ethanediol (14), (2S)-L-3-phenyllactic acid (15), papuline [or (2S)-L-3-phenyllactic acid methyl ester, 16], 2′-epi terpendole A (17), terpendoles C (18) and D (19), cholic acid, and zeorin were isolated from the entomopathogenic fungus Aschersonia confluens BCC53152. Their chemical structures were elucidated on the basis of NMR spectroscopic and mass spectrometric analyses. The absolute configurations were determined by using the evidence from NOESY correlations, chemical means, optical rotation values together with comparison of ECD spectroscopic data with the calculated ECD spectra. The plausible biosynthetic pathway of compounds 1–3 was also proposed. Moreover, antimicrobial activity such as antimalarial, antitubercular, antifungal, and antibacterial activities and cytotoxicity against cancerous (MCF-7, KB, and NCI-H187) and non-cancerous (Vero) cells of the isolated compounds were evaluated.

KMITL

Browse

Filters

Settings

Sort By

Results per page

Search Results