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Author: search.filters.author.Damrongsak, PattareeyaSubject: search.filters.subject.Nanoparticles

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    Antiradical properties of chemo drug, carboplatin, in cooperation with ZnO nanoparticles under UV irradiation in putative model of cancer cells
    (2019-07-01)
    Pairoj, Suttirak
    ;
    Damrongsak, Pattareeya
    ;
    Damrongsak, Badin
    ;
    Jinawath, Natini
    ;
    Kaewkhaw, Rossukon
    The main objective of this study was to assess the antiradical properties of zinc oxide (ZnO) nanoparticles upon exposure to ultraviolet radiation with carboplatin, an anti-proliferative drug used in the treatment of retinoblastoma. For the purpose of this study, the decomposition of 2,2(diphenyl-1-picryhydrazyl) radical (DPPH*) was used to assess the free radical capacity of antioxidants and was followed by MTT measurements. To test the antiradical capacity, the effective concentration, antiradical power, stoichiometry, and number of reduced DPPH* were investigated. DPPH* has a peak absorbance at a wavelength of 515 nm, which disappears upon the introduction of the antiradical agents. Four agents were reacted with DPPH* and represented the possible reaction kinetic categories. ZnO nanoparticles and carboplatin-loaded ZnO nanoparticles reacted more strongly with DPPH* and approached a saturation state at 420 min. The remaining two antiradical agents, ZnO nanoparticles under UV radiation and carboplatin-loaded ZnO nanoparticles under UV radiation, reacted a bit slower with DPPH* and approached a steady state at 1440 min. Among the different four antiradical agents, carboplatin-loaded ZnO nanoparticles under UV light had the highest antiradical response with the lowest effective concentration value to the reduced DPPH* molecules. ZnO nanoparticles alone were found to be poor antiradical agent. Possible mechanisms were attributed to the number of hydroxyl groups available to decrease the number of DPPH*.
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    Optical imaging of artificial latent fingerprints using rhodamine 6G and au-core/Pd-shell nanorods
    (2019-01-01)
    Locharoenrat, Kitsakorn
    ;
    Damrongsak, Pattareeya
    Latent fingerprints represent valuable information-storage platforms, which play a key role in the forensic practice and health assessment. Recent works have explored novel image-enhancement methods in latent fingerprinting, which are associated with fluorescence dyes. In this study we improve the quality of fingerprint images, using a combination of fluorescence dyes and bimetallic nanoparticles. We find that Rhodamine 6G can serve as a kind of ‘glue’ adhering well onto Au–Pd core–shell nanorods. This system which employs molecules like α- amylase can be successfully used for recognition of artificial latent fingerprints. The appropriate mechanism can be coupling of localized surface plasmon resonance in the nanorods mentioned above and the emission of Rhodamine 6G. As a result, we observe notable enhancement of the images of artificial latent fingerprints.
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    Rhodamine 6G and Au–Pd core–shell nanorods: Fluorescence enhancement for detection of mercury
    (2018-01-01)
    Rammarat, Ekkachai
    ;
    Kraithong, Sasiwimon
    ;
    Wanichacheva, Nantanit
    ;
    Swanglap, Pattanawit
    ;
    Yindeesuk, Witoon
    We show that hybrid organic–inorganic particles are efficient for accurate sensing of mercury ions and following up trace amounts of the mercury pollutions spread in the environment. The process of synthesis of a working substance starts from preparation of rhodamine 6G derivative. Then the dye molecules are bound on the surface of Au–Pd core–shell nanorods. Mercury ions with different concentrations are finally attached onto this fluorescence sensor. Fluorescence emission of the sensor is detected with a luminescence spectrophotometer. The experimental results demonstrate that the fluorescence intensity of one of our sensors, a sensor B, is remarkably enhanced when the mercury-ion concentration increases from 0 to 15.5 µM. The limit of detection of the ions is as low as 20.6 nM. The working mechanism of our fluorescence sensor can be explained through the fluorescence-energy transfer and the plasmonic effect associated with spirolactam forms of rhodamine and conducting bimetallic nanoparticles.