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Author: search.filters.author.Kaewpirom, SupraneeSubject: search.filters.subject.Silk fibroin

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    Item type:Publication,
    Tailoring silk fibroin hydrophilicity and physicochemical properties using sugar alcohols for medical device coatings
    (2024-12-01)
    Kaewpirom, Supranee
    ;
    Piboonnithikasem, Sarayoot
    ;
    Sroisroemsap, Pongsathorn
    ;
    Uttoom, Sittichai
    ;
    Boonsang, Siridech
    This study explores the modification of silk fibroin films for hydrophilic coating applications using various sugar alcohols. Films, prepared via solvent casting, incorporated glycerol, sorbitol, and maltitol, revealing distinctive transparency and UV absorption characteristics based on sugar alcohol chemical structures. X-ray diffraction confirmed a silk I to silk II transition influenced by sugar alcohols. Glycerol proved most effective in enhancing the β-sheet structure. The study also elucidated a conformational shift towards a β-sheet structure induced by sugar alcohols. Silk fibroin–sugar alcohol blind docking and sugar alcohol-sugar alcohol blind docking investigations were conducted utilizing the HDOCK Server. The computer simulation unveiled the significance of size and hydrogen bonding characteristics inherent in sugar alcohols, emphasizing their pivotal role in influencing interactions within silk fibroin matrices. Hydrophilicity of ozonized silicone surfaces improved through successful coating with silk fibroin films, particularly glycerol-containing ones, resulting in reduced contact angles. Strong adhesion between silk fibroin films and ozonized silicone surfaces was evident, indicating robust hydrogen bonding interactions. This comprehensive research provides crucial insights into sugar alcohols’ potential to modify silk fibroin film crystalline structures, offering valuable guidance for optimizing their design and functionality, especially in silicone coating applications.
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    Highly-transparent multi-layered spin-coated silk fibroin film
    (2017-01-01)
    Wasapinyokul, Kamol
    ;
    Kaewpirom, Supranee
    ;
    Chuwongin, Santhad
    ;
    Boonsang, Siridech
    In this study, the silk fibroin films with different numbers of layers were fabricated by the spin-coating method and their optical transmittances were observed. The process to synthesise the silk fibroin solution was explained - starting from the silk cocoon until the silk-fibroin solution, approximately 7.5% concentration wt/vol, was obtained. The solution was spin-coated onto clean glass substrates to fabricate samples. Totally 10 samples with different numbers of layers, from 1 to 5 layers, were obtained. All samples can be separated into two groups: those left dried at room temperature after spin-coating and those heated at 60°C. They were then measured for their transmittance over the visible-to-near-infrared region. All samples exhibited the high transmittance where the values were at 95% and 98%, for the samples at room temperature and those at 60°C, respectively. This was believed to be due to the heating effect that caused the silk fibroin to arrange itself after being heated, hence the higher transmittance. These high transmittances were maintained regardless of the number of layers and length of heating time. Results from this study could be used to fabricate a silk fibroin film with high optical transmittance and adjustable other properties.