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Author: search.filters.author.Kameshima, YoshikazuSubject: search.filters.subject.Protein

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    Hydroxyapatite formation on CaSiO3 ceramics in protein containing system
    (2001-01-01)
    Okada, Kiyoshi
    ;
    Siriphannon, Punnama
    ;
    Kameshima, Yoshikazu
    ;
    Yasumori, Atsuo
    ;
    Hayashi, Shigeo
    α-CaSiO<inf>3</inf> ceramics with a nominal composition of CaO 46.0, SiO<inf>2</inf> 54.0, and Na<inf>2</inf>O 0.4 wt% were soaked in two different solutions, simulated body fluid (SBF) and α-minimum essential medium (α-MEM), to study the effect of protein on the formation of hydroxyapatite (HA). The SBF solution contained the same inorganic salts as in the human blood plasma, while the α-MEM solution contained both inorganic salts and various proteins. Both soaking systems were maintained at 36.5°C and a flow rate of about 40 ml/day for various periods of times. A complete coating of HA formed on the surface of the α-CaSiO<inf>3</inf> ceramics in both solutions, but with different formation behavior and microstructure. The HA formed in the α-MEM system had ball-like particle morphology with a smaller particle size than the material formed in the SBF system. Cristobalite and/or unknown silicate phase coprecipitate with the HA in the α-MEM system but not in SBF. The HA layer formed on the ceramic surface achieved a thickness of about 80 and 93 μm after 20 days soaking in SBF and α-MEM solutions, respectively. The presence of protein in the α-MEM solution was considered to effect the microstructure of HA and possibly enhanced HA precipitation on the α-CaSiO<inf>3</inf> ceramic. © 2002 Trans Tech Publications, Switzerland.
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