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Author: search.filters.author.Kulchat, SirinanSubject: search.filters.subject.antibacterial

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    Item type:Publication,
    A Shear-Thinning, Self-Healing, Dual-Cross Linked Hydrogel Based on Gelatin/Vanillin/Fe3+/AGP-AgNPs: Synthesis, Antibacterial, and Wound-Healing Assessment
    (2023-12-01)
    Talodthaisong, Chanon
    ;
    Patramanon, Rina
    ;
    Thammawithan, Saengrawee
    ;
    Lapmanee, Sarawut
    ;
    Maikaeo, Lamai
    A shear-thinning and self-healing hydrogel based on a gelatin biopolymer is synthesized using vanillin and Fe<sup>3+</sup> as dual crosslinking agents. Rheological studies indicate the formation of a strong gel found to be injectable and exhibit rapid self-healing (within 10 min). The hydrogels also exhibited a high degree of swelling, suggesting potential as wound dressings since the absorption of large amounts of wound exudate, and optimum moisture levels, lead to accelerated wound healing. Andrographolide, an anti-inflammatory natural product is used to fabricate silver nanoparticles, which are characterized and composited with the fabricated hydrogels to imbue them with anti-microbial activity. The nanoparticle/hydrogel composites exhibit activity against Escherichia coli, Staphylococcus aureus, and Burkholderia pseudomallei, the pathogen that causes melioidosis, a serious but neglected disease affecting southeast Asia and northern Australia. Finally, the nanoparticle/hydrogel composites are shown to enhance wound closure in animal models compared to the hydrogel alone, confirming that these hydrogel composites hold great potential in the biomedical field.
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