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Author: search.filters.author.Pitpisutkul, VipawanSubject: search.filters.subject.Starch

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    Porous antimicrobial crosslinked film of hydroxypropyl methylcellulose/carboxymethyl starch incorporating gallic acid for wound dressing application
    (2024-01-01)
    Pitpisutkul, Vipawan
    ;
    Prachayawarakorn, Jutarat
    Because of weak mechanical qualities and low degree of swelling of hydroxypropyl methylcellulose/carboxymethyl starch (HP/CMS) blended films for wound dressing application, this work prepared a unique antimicrobial crosslinked film utilizing succinic acid (SA) as a non-toxic crosslinker and gallic acid (GAL) as an antibacterial agent. It was observed that the infrared-shifted peak position of O[sbnd]H stretching and bending in HP/CMS/SA/GAL films was caused by hydrogen bond formation among HP, CMS and GAL components. The antimicrobial crosslinked films considerably enhanced their mechanical properties and swelling degree. After adding SA and GAL, the films retained their porosity structure as observed by scanning electron images. Moreover, GAL-loaded HP/CMS/SA films could inhibit Staphylococcus aureus and Escherichia coli growth, showing their wound dressing potential. Crystallinity percentage, water vapor transmission rate, gel fraction, water solubility, water uptake and cytotoxicity were also investigated.
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    Hydroxypropyl methylcellulose/carboxymethyl starch/zinc oxide porous nanocomposite films for wound dressing application
    (2022-12-15)
    Pitpisutkul, Vipawan
    ;
    Prachayawarakorn, Jutarat
    Because of low moisture uptake, water vapor transmission rate, oxygen transmission rate, swelling capacity and no antibacterial activity of hydroxypropyl methylcellulose (HPMC) film, carboxymethyl starch (CMS) and zinc oxide nanoparticles (ZnO-NPs) were incorporated in order to improve its limitations for wound dressing application. The infrared shifted peak of O–H stretching and O–H bending in HPMC/CMS blended films was detected due to hydrogen bond formation between HPMC and CMS. Scanning electron images of HPMC/CMS blended films exhibited porous structure. In addition, swelling degree, moisture uptake, water vapor transmission rate and oxygen transmission rate of HPMC/CMS blended films with various contents of CMS clearly increased compared to HPMC film. Moreover, HPMC/CMS nanocomposite films loaded with ZnO-NPs showed good antibacterial activity against Staphylococcus aureus and Escherichia coli, revealing their potential for wound dressing application. Percentage of crystallinity, cytotoxicity, mechanical and thermal properties were also examined.