We have proposed a data acquisition system with high speed USB interface using FPGA chip as the main processing unit. Since the FPGA has a number of modules on chip, which can operate independently, it can be utilized for the data acquisition system with multi-channels for the connection to four ADC signals with four different protocols of Parallel, SPI, I<sup>2</sup>C and one-wire protocol. The system is controlled by the software written in the visual C<sup>++</sup>. It allows the user to be able to interface to a PC for data restoration and monitoring. We found that this system can perform data acquisition with high rate data transfer.
