KMITL

Permanent URI for this communityhttps://dspace.kmitl.ac.th/handle/123456789/1

Browse

Settings

Author: search.filters.author.Sangkhun, WeradeshHas files: No

Search Results

Now showing 1 - 4 of 4
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Methyl Gallate and Amoxicillin-Loaded Electrospun Poly(vinyl alcohol)/Chitosan Mats: Impact of Acetic Acid on Their Anti-Staphylococcus aureus Activity
    (2025-01-01)
    Jiamboonsri, Pimsumon
    ;
    Sangkhun, Weradesh
    ;
    Wanwong, Sompit
    Methyl gallate (MG), a natural phenolic compound, exhibits in vitro synergistic activity with amoxicillin (Amox) against methicillin-resistant Staphylococcus aureus (MRSA), a global health concern. This study developed electrospun nanofibers incorporating MG and Amox into a poly(vinyl alcohol) (PVA)/chitosan (CS) blend to target both methicillin-susceptible S. aureus (MSSA) and MRSA. The formulation was optimized, and the impact of acetic acid on antibacterial activity was evaluated using agar disc diffusion. The final formulation was fabricated and characterized using SEM, FTIR, DSC, swelling, and release behavior analyses to understand its antibacterial efficacy. Results revealed that acetic acid eliminated antibacterial activity, but MG (64 mg/mL) and Amox (2.5 mg/mL) were successfully incorporated into a PVA/CS solution prepared with deionized water. The resulting nanofiber mats featured nanoscale fibers (126 ± 45 nm) with and micron-oval beads. Despite the in vitro synergism, the MG/Amox/PVA/CS mats showed no significant improvement over MG or Amox alone against MRSA, likely due to their physicochemical properties. FTIR and DSC results confirmed molecular interactions between the active compounds and the polymer matrix, which may cause a minimal swelling and low drug release at 24 h. This study offers insights into the potential of MG/Amox-loaded nanofibers for anti-MRSA material development.
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Electrospun Cellulose Acetate/Poly(Vinyl Alcohol) Nanofibers Loaded with Methyl Gallate and Gallic Acid for Anti-Staphylococcus aureus Applications
    (2024-11-01)
    Jiamboonsri, Pimsumon
    ;
    Sangkhun, Weradesh
    ;
    Wanwong, Sompit
    Methyl gallate (MG) and gallic acid (GA) are natural compounds with potent activity against methicillin-resistant Staphylococcus aureus (MRSA), a significant global health concern. In this study, MG and GA were incorporated into cellulose acetate (CA) blended with poly(vinyl alcohol) (PVA) to create electrospun nanofibers aimed at combating both methicillin-susceptible S. aureus (MSSA) and MRSA. Key electrospinning parameters—DC voltage, injection flow rate, and syringe tip–collector distance—were optimized, with the best conditions being a 1.5 mL/h flow rate, 30 cm distance, and 20 kV voltage. The resulting nanofiber mats were characterized by SEM, FTIR, DSC, tensile strength testing, contact angle measurement, swelling behavior, and release profiling. Antibacterial properties were assessed using the agar diffusion test. The obtained nanofibers had diameters ranging from 879.33 to 906.13 nm. Among the samples, MG-GA-CA/PVA exhibited the highest tensile strength, good flexibility, and improved stiffness, which was related to enhanced thermal stability and chemical interactions as shown by DSC and FTIR analyses. This formulation also displayed excellent hydrophilicity, swelling properties, and a consistent release profile over 8 to 24 h. Furthermore, MG-GA-CA/PVA showed superior antibacterial activity against both MSSA and MRSA, suggesting its potential as a strong, flexible, and effective anti-S. aureus material.
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Electrospun silk nanofiber loaded with Ag-doped TiO2 with high-reactive facet as multifunctional air filter
    (2023-08-29)
    Wanwong, Sompit
    ;
    Sangkhun, Weradesh
    ;
    Jiamboonsri, Pimsumon
    ;
    Butburee, Teera
    Particulate matter (PM) and volatile organic compounds (VOCs) are air pollution that can cause high risk to public health. To protect individuals from air pollution exposure, fibrous filters have been widely employed. In this work, we develop silk nanofibers, which are loaded with Ag-doped TiO<inf>2</inf> nanoparticles with exposed (001) (assigned as Ag-TiO<inf>2</inf>-silk), via electrospinning method and utilized them as multifunctional air filters that can efficiently reduce PM<inf>2.5</inf>, organic pollutants and microbials. The results showed that Ag-TiO<inf>2</inf>-silk with a loading of 1 wt% (1%Ag-TiO<inf>2</inf>-silk) exhibited the best performance among various different Ag-doped samples, as it performed the best as an air filter, which had the highest PM<inf>2.5</inf> removal efficiency of 99.04 ± 1.70% with low pressure drop of 34.3 Pa, and also exhibited the highest photodegradation efficiency of formaldehyde. In addition, the Ag-TiO<inf>2</inf>-silk demonstrated antibacterial activity. These properties make silk composite nanofibers attractive for multifunctional and environmentally-friendly air filter application.
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Electrospun Cyclodextrin/Poly(L-lactic acid) Nanofibers for Efficient Air Filter: Their PM and VOC Removal Efficiency and Triboelectric Outputs
    (2023-02-01)
    Wanwong, Sompit
    ;
    Sangkhun, Weradesh
    ;
    Jiamboonsri, Pimsumon
    In this work, PLLA and CD/PLLA nanofibers were fabricated using electrospinning and utilized as a particulate matter (PM) and volatile organic compounds (VOCs) filter. The electrospun PLLA and CD/PLLA were characterized with various techniques, including SEM, BET, FTIR, XRD, XPS, WCA, DSC, tensile strength testing, PM and VOCs removal efficiency, and triboelectric performance. The results demonstrated that the best air filter was 2.5 wt%CD/PLLA, which performed the highest filtration efficiencies of 96.84 ± 1.51% and 99.38 ± 0.43% for capturing PM<inf>2.5</inf> and PM<inf>10</inf>, respectively. Its PM<inf>2.5</inf> removal efficiency was 16% higher than that of pure PLLA, which were contributed by their higher surface area and porosity. These 2.5 wt%CD/PLLA nanofibers also exhibited the highest and the fastest VOC entrapment. For triboelectric outputs, the 2.5 wt%CD/PLLA-based triboelectric nanogenerator provided the highest electrical outputs as 245 V and 84.70 μA. These give rise to a three-fold enhancement of electrical outputs. These results indicated that the 2.5 wt%CD/PLLA can improve surface charge density that could capture more PM via electrostatic interaction under surrounding vibration. Therefore, this study suggested that 2.5 wt%CD/PLLA is a good candidate for a multifunction nanofibrous air filter that offers efficient PM and VOC removal.