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Chaetomium: Goldmine for Sustainable Agriculture
(2026-01-01)
Soytong, Kasem
;
Song, Jiaojiao
Chaetomium species are saprophytic fungi that are valuable resources for sustainable agriculture. It is found all over the world because it is durable and survives in living organisms in different climates. Chaetomium species are mostly ascomycete saprophytic fungi that survive well under stressful environmental conditions. This area has become one of the gold mines for sustainable agricultural production to maintain a balanced ecological system. The specific, potent isolates of Chaetomium were found to protect economic plants through disease, insect, and nematode control and to strongly produce cellulase to degrade organic materials in the fermentation process to increase soil nutrient fertility. All the discovered strains are recommended for acute and dermal toxicity, screening for agrochemical resistance and durability in different climates, including acidic or alkaline conditions, and growing in a wide range of temperature regimes. Research has revealed that Chaetomium species can be developed as biological fungicides, biological insecticides, biological nematicides, and natural active metabolites for plant disease control as well as biosensors for soil revitalization. These bioproducts can be used for sustainable agricultural development and maintain biological diversity in surrounding environments. Research on microbial products of Chaetomium species and other fungi for plant disease control has been conducted since 1989. After several years, 22 effective strains of Chaetomium were discovered and patented as broad-spectrum microbial fungicides, noted as Patent No. 6266, International Code: AO 1 N 25/12, and then registered as Ketomium® microbial fungicides in Thailand, Laos, Cambodia, and Vietnam and as microbial fertilizers in P. R. China. Chaetomium as a microbial fungicide and microbial fertilizer can be applied in combination with integrated pest management (IPM). It has been shown to have pathogen and disease suppressive, curative, and protective effects to control plant diseases. It is strongly recommended to prove acute and dermal toxicity, agrochemical resistance screening, acidity or alkaline conditions, and temperature regimes before developing microbial fungicides and microbial fertilizers. Chaetomium spp. are distributed worldwide and survive well under stress conditions. It serves as a natural goldmine for sustainability to maintain and revitalize the environment and preserve the natural and ecological balance in nature. Chaetomium species are broad habitats in soil, water, and endophytes with various biological properties of antagonists of phytopathogens, some insects, plant parasitic nematodes, and human pathogens, as well as the production of active metabolites, enzymes, etc.
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Microbial Nanotechnology in Agricultural Applications
(2026-01-01)
Song, Jiaojiao
;
Soytong, Kasem
Nanotechnology has been developed for plant disease management, and many kinds of organic nanoparticles have been developed to induce the immunity of plants, such as plant vaccines. Natural products from Chaetomium lucknowense, Chaetomium brasiliense, Chaetomium cochliodes, Chaetomium cupreum, Chaetomium elatum, Chaetomium globosum, Chaetomium siamense, Emericella nidulans, Trichoderma harzianum, and Trichoderma hamatum are reported to have antimicrobial activities against plant pathogens. In particular, Ch. siamense is a newly discovered and endophytic Chaetomium spp. that produces active metabolites. These active metabolites from Chaetomium spp., E. nidulans, T. harzianum, and T. hamatum are constructed as nanofibers for inducing plant disease immunity through phytoalexin production as nanoplant vaccines. The nanofibers are used as elicitors for the induction of immunity in plants that induce phytoalexin biosynthesis, for example, scopoletin and anthocyanidin against Phytophthora or Pythium rot and scoparone against Phytophthora or Pythium rot, capsidiol in chili against anthracnose, alpha-tomatine in tomato against Fusarium wilt, and sakuranetin and oryzalexin in rice plants against blast. The natural product nanoelicitors derived from Chaetomium spp., Emericella spp., and Trichoderma spp. help reduce disease incidence in plants.
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Nanoparticles Derived from Active Metabolites of Chaetomium cupreum CC3003 against Phytophthora Rot of Durian
(2022-01-01)
Tongon, Rujira
;
Soytong, Kasem
Phytophthora rot of durian (Durio zibetinus L.) is a serious disease wherever the crop has been planted and the disease control customarily uses chemical fungicides reported to be resistant by pathogen. Alternative non-chemical control strategies are being investigated to produce safe food. The main objective of this research was to test the activity of metabolites from Chaetomium cupreum CC3003 in the form of crude materials and nanoparticles to control and induce immunity to Phytophthora palmivora causing rot of durian var. Monthong. The results showed that P. palmivora proved to be pathogenic to durian var. Monthong. C. cupreum CC3003 acted as an antagonist and P. palmivora was confirmed as the pathogen by morphological and molecular genetic identification. Effective doses (ED50) of CC-E, CC-H and CC-M crude metabolites for spore inhibition were 60, 97 and 140 mg.kg-1, respectively. The research findings found that the diameters of nano CC-E, nano CC-H and nano CC-M were 534, 499 and 537 nm, respectively. The nano CC-E, nano CC-H and nano CC-M demonstrated antifungal activity against P. palmivora with ED50 of 11, 13 and 16 mg.kg<sup>-1</sup>, respectively. The nanoparticles at low concentrations were more effective than crude metabolites at high concentrations. Nano-CC-E used to treat seedlings of durian resulted in the production of scopoletin which served as an immunity agent or elicitor against rot disease of durian. It is concluded that active metabolites derived from C. cupreum significantly inhibited P. palmivora and induced immunity through phytoalexin production
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Nano-particle derived from chaetomium cuprem cc3003 against anthracnose of coffee var. Arabica
(2018-01-01)
Somlit, Vilavong
;
Somdej, Kanokmedhakul
;
Kaunchai, Kanokmedhakul
;
Soytong, Kasem
Colletotrichum gloeosporioides is proved to be a pathogenic isolate causing anthracnose disease on coffee var. Arabica in Lao PDR. Chaetomium cupreum CC3003 inhibits sporulation of C. gloeosporiodes by 42.60 % in 30 days. The tested nano CCH, nano CCE and nano CCM derived from C. cupreum CC3003 significantly inhibits C. gloeosporioides that cause coffee anthracnose at low concentrations of about 3-15 ppm. The tested nano-particles applied to inoculated coffee seedlings significantly reduce coffee anthracnose. Research and development on nano-particles extracted from fungi are necessary to discover new strategies to control plant disease.
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Cytotoxic 10-(indol-3-yl)-[13]cytochalasans from the fungus Chaetomium elatum ChE01
(2010-08-01)
Thohinung, Santi
;
Kanokmedhakul, Somdej
;
Kanokmedhakul, Kwanjai
;
Kukongviriyapan, Veerapol
;
Tusskorn, Ornanong
Nine 10-(indol-3-yl)-[13]cytochalasans such as a new chaetoglobosin V (1); two new natural products, prochaetoglobosin III (2) and prochaetoglobosin III<inf>ed</inf> (3); six known chaetoglobosins B-D (4-6), F (7), and G (8) and isochaetoglobosin D (9) in addition to two known sterols, 24(R)-5α, 8α-epidioxyergosta-6-22-diene-3β-ol (10) and ergosterol (11), were isolated from the fungus Chaetomium elatum ChE01. The structures of these compounds were elucidated by spectroscopic methods. Compounds 1-9 showed cytotoxicity against the human breast cancer (IC<inf>50</inf> 2.54-21.29 μM) and cholangiocarcinoma cell lines (IC<inf>50</inf> 3.41-86.95 μM). © 2010 The Pharmaceutical Society of Korea and Springer Netherlands.
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Bis-spiro-azaphilones and azaphilones from the fungi Chaetomium cochliodes VTh01 and C. cochliodes CTh05
(2008-09-29)
Phonkerd, Nutchanat
;
Kanokmedhakul, Somdej
;
Kanokmedhakul, Kwanjai
;
Soytong, Kasem
;
Prabpai, Samran
Four new dimeric spiro-azaplilones, cochliodones A-D (1-4), two new azaphliones, chaetoviridines E and F (5 and 6), a new epi-chaetoviridin A (7), together with five known compounds, chaetoviridin A (8), ergosterol (9), chaetochalasin A (10), 24(R)-5α,8α-epidioxyergosta-6-22-diene-3β-ol (11), and ergosterol-β-d-glucoside (12) were isolated from the fungi Chaetomium cochliodes VTh01 and C. cochliodes CTh05. Structures and stereochemistry of the atropisomers 1-3 were determined by single-crystal X-ray diffraction analysis. Compounds 5, 10, and 11 exhibited antimalarial activity against Plasmodium falciparum, while 3, 5, 6, 10, and 11 showed antimycobacterial activity against Mycobacterium tuberculosis. In addition, 5 and 6 also showed cytotoxicity against the KB, BC1, and NCI-H187 cell lines. © 2008 Elsevier Ltd. All rights reserved.

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