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Author: search.filters.author.Treethong, AlongkotSubject: search.filters.subject.Surfactant

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    Surfactant effect on the physicochemical characteristics of γ-oryanol-containing solid lipid nanoparticles
    (2016-01-05)
    Karn-orachai, Kullavadee
    ;
    Smith, Siwaporn Meejoo
    ;
    Saesoo, Somsak
    ;
    Treethong, Alongkot
    ;
    Puttipipatkhachorn, Satit
    Surfactants employed in production of solid lipid nanoparticles (SLNs) play a major role on physical stability of nanoparticles, and the extent of drug dissolution and permeability into cells. In this study, cationic (cetyl pyridinium chloride), anionic (sodium dodecyl sulfate) and non-ionic (Tween 80) surfactants, as well as its combinations, were employed to formulate compritol based SLNs using γ-oryzanol as a model drug. The physicochemical properties of drug-loaded SLNs are influenced by the surfactant composition systems. Surfactant blend systems gave SLNs with superior stability compared with single surfactant systems due to enhanced incorporation of the drug within the solid lipid matrix. This may be due to synergic effects arising from electrostatic repulsion of the surfactant charges (ionic), the steric hindrance of surfactant structure (non-ionic), and ion-pairing effects between cationic and anionic ones. The cytotoxicity results demonstrated that positively charged SLNs can be uptaken into cells to a high extent. Nevertheless, the mixed surfactant systems (cationic/non-ionic and cationic/anionic/non-ionic), have remarkable advantages providing SLNs with high cell internalization capability, however, low cytotoxicity. This systematic investigation may give an insight into the practical integration of multi-surfactant systems to achieve non-toxic and highly effective drug delivery systems.
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    The effect of surfactant composition on the chemical and structural properties of nanostructured lipid carriers
    (2014-01-01)
    Karn-Orachai, Kullavadee
    ;
    Smith, Siwaporn Meejoo
    ;
    Phunpee, Sarunya
    ;
    Treethong, Alongkot
    ;
    Puttipipatkhachorn, Satit
    Fine-tuning the nanoscale structure and morphology of nanostructured lipid carriers (NLCs) is central to improving drug loading and stability of the particles. The role of surfactant charge on controlling the structure, the physicochemical properties and the stability of NLCs has been investigated using three surfactant types (cationic, anionic, non-ionic), and mixed surfactants. Either one, a mixture of two, or a mixture of three surfactants were used to coat the NLCs, with these classified as one, two and three surfactant systems, respectively. The mixed (two and three) surfactant systems produced smaller NLC particles and yielded NLCs with lower crystallinity than the one surfactant system. The combined effects of the ionic and the non-ionic surfactants may play a key role in assisting the lipid-oil mixing, as well as maintaining colloidal repulsion between NLC particles. In contrast, for the three surfactant system, the lipid-oil mixture in the NLCs appeared less homogenous. This was also reflected in the results of the stability study, which indicated that NLC particle sizes in two surfactant systems appeared to be retained over longer periods than for other surfactant systems. © 2014 Informa UK Ltd.