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Subject: search.filters.subject.Polycaprolactone

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    Preparation and evaluation of blend polymer films for wound dressing using vancomycin-loaded polycaprolactone and carboxymethyl cellulose via crosslinking methods: Effect of mechanical strength, antibacterial activity, and cytotoxicity
    (2024-03-01)
    Meedecha, Paweena
    ;
    Srisang, Naruebodee
    ;
    Eawsakul, Komgrit
    ;
    Ongtanasup, Tassanee
    ;
    Tambunlertchai, Supreeda
    Polycaprolactone (PCL) and carboxymethyl cellulose (CMC) are two materials with beneficial properties for wound healing applications. Here, the simple preparation of PCL/CMC polymer films via the crosslinking method was demonstrated for the first time. The polymer films represented the suitable properties of liquid absorption and tensile strength to be used as a wound dressing. The blend polymer films can also load the vancomycin, which prolongs the drug release for effectiveness against S. aureus. The trifluoroethanol showed less toxicity in comparison with other crosslinking agents. This process can also be applied further in other medical devices and wound healing applications.
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    TMPZnN(SiMe3)2, [TMPZn(μ-OiPr)]2 and TMPZn[OCMe2C(O)OEt]. Their role in the ring-opening of rac-lactide and ϵ-caprolactone where TMP = 1,5,9-trimesityldipyrromethene
    (2016-06-15)
    Balasanthiran, Vagulejan
    ;
    Chisholm, Malcolm H.
    ;
    Choojun, Kittisak
    ;
    Durr, Christopher B.
    ;
    Wambua, Pasco M.
    From the reaction between Zn[N(SiMe<inf>3</inf>)<inf>2</inf>]<inf>2</inf> and TMP-H (1 equiv.) in toluene at room temperature TMPZn[N(SiMe<inf>3</inf>)<inf>2</inf>] was prepared and subsequently reacted with Pr<sup>i</sup>OH (1 equiv.) and HOCMe<inf>2</inf>C(O)OEt (1 equiv.) to give [TMPZn(μ-OPr<sup>i</sup>)]<inf>2</inf> and TMPZn[OCMe<inf>2</inf>C(O)OEt], respectively. The three compounds were each crystallized and characterized by single crystal X-ray diffraction. The compound TMPZn[N(SiMe<inf>3</inf>)<inf>2</inf>] was a three coordinated N<inf>3</inf>Zn compound with an anagostic N(SiMe<inf>3</inf>)<inf>2</inf> ligand where one SiMe<inf>3</inf> was annexed to the Zn<sup>2+</sup> ion. The compound [TMPZn(μ-OPr<sup>i</sup>)]<inf>2</inf> has a molecular C<inf>2</inf> axis and is dimeric in toluene-d<inf>8</inf> solution having a N<inf>2</inf>ZnO<inf>2</inf> core for each Zn<sup>2+</sup> ion. In TMPZn[OCMe<inf>2</inf>C(O)OEt] compound the Zn<inf>2</inf> + ion is four-coordinated. This too is present in solution (IR) and also present in toluene-d<inf>8</inf> and THF where there is evidence of fluxionality with T<inf>c</inf> ∼15 °C and -85 °C, respectively. The compound [TMPZn(μ-OPr<sup>i</sup>)]<inf>2</inf> polymerizes both ϵ-caprolactone (ϵ-CL) and rac-lactide (rac-LA) to give polycaprolactone (PCL) and polylactic acid (PLA), respectively. The rate of the reactions are ϵ-CL > LA and are influenced by the nature of solvent, THF > CD<inf>2</inf>Cl<inf>2</inf>/CH<inf>2</inf>Cl<inf>2</inf>. The nature of PLA derived from rac-LA is heterotactic: P<inf>r</inf> = 0.96 in THF and P<inf>r</inf> = 0.75 in CD<inf>2</inf>Cl<inf>2</inf>/CH<inf>2</inf>Cl<inf>2</inf>. In the copolymerization of rac-LA: ϵ-CL by both [TMPZn(μ-OPr<sup>i</sup>)]<inf>2</inf> and TMPZn[OCMe<inf>2</inf>C(O)OEt] only PLA is produced, PCL is not formed.