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    Influence of a Non-ionic Surfactant on the Release of Rhodamine B from Poly(vinyl) Alcohol/Polyoxalate/Span-80 Composite Nanofibers Prepared by Emulsion Electrospinning
    (2024-10-26)
    Phromviyo, Nutthakritta
    ;
    Chompoosor, Apiwat
    ;
    Teerasong, Saowapak
    Controlling drug release using a nanocomposite method is crucial; however, burst release must be avoided in order to obtain effective controllable drug release. In this study, poly(vinyl) alcohol/polyoxalate/Span-80 (PVA/ POX/ Span-80) composite nanofibers loaded with Rhodamine B were produced using emulsion electrospinning. The objective of this work was to evaluate the cooperative roles of POX and Span-80 on nanofibrous scaffold stability and drug release regulation by monitoring Rhodamine B release performance from electrospun composite nanofibers. The microstructure and hydrophilic properties of the emulsion electrospun nanofibers were studied using scanning electron microscopy (SEM), water contact angle, and swelling tests. According to the results, increasing the POX content had a significant effect on the size of nanofibers. The water contact angles increased as the POX content increased. The release of Rhodamine B was governed by a two-stage diffusion mechanism that was greatly influenced by PVA/POX ratios and Span-80. To compare release behavior, non-emulsion electrospun nanofibers without Span-80 were prepared as control samples. Emulsion nanofibers were found to release at a slower rate than non-emulsion nanofibers. The in vitro release profiles revealed that Rhodamine B was released from emulsion electrospun fibers in a sustainable manner and that no initial burst release was observed. These findings imply that emulsion electrospun nanofibers can potentially be used to deliver drugs, nutraceuticals, and fragrances in a prolonged manner.
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    Formulation Development of Serum Beads: Investigating the Influence of Sodium Alginate/Iota Carrageenan Ratio on Bead Characteristics
    (2024-05-01)
    Woraphokanunt, Yada
    ;
    Teeranachaideekul, Veerawat
    ;
    Rittiboon, Aree
    ;
    Jatupornpipat, Marisa
    Background and Objectives: To develop cosmetic products by using Ionic gelation techniques as the main technique in the production of serum beads. The purpose of this study is to develop the serum beads recipe by studying the ratio of various types of gelling agents for complete serum beads products. Methodology: Test the ratio of gelling agents in serums that create beads with ionic gelation techniques by Sodium Alginate and Iota-carrageenan which affect the appearance and beads texture after forming. Then compare the concentration of the gelling agent used in the suspension of serum beads that affects the ability to suspend serum beads. In this study, Carbopol® ultrez 20 was selected as the type of gelling agent. Main Results: The most suitable ratio for forming serum beads between Sodium Alginate and Iota-carrageenan is 0.20:0.30. Because the appearance of serum beads is spherical which can be pressed, cracked and spread on the surface easily-moderately, which is the most suitable characteristic for serum beads compared with the other ratios. When the serum beads were suspended inside the Carbopol® ultrez 20 gel at different concentrations and sensory tests, it was found that Carbopol® ultrez 20 at a concentration of 0.70 percent was the most favored. After storing in accelerated conditions to test the stability of the product, it was found that all concentrations of the gelling agent Carbopol® ultrez 20 could make the serum beads suspended and disperse inside the gel, but the viscosity was significantly reduced in each formulation. Conclusions: Conclusion: The ratio of Sodium Alginate and Iota-carrageenan affects the formation and hardness of beads. The most suitable ratio in this study is 0.20:0.30 and the gelling agent Carbopol® ultrez 20 at a concentration of 0. 70 percent is the most suitable choice for using as a suspension gel in the serum bead cosmetic formula. Because it is the most stable and has the least change when stored in accelerated condition for 8 weeks.