KMITL

Permanent URI for this communityhttps://dspace.kmitl.ac.th/handle/123456789/1

Browse

Search Results

Now showing 1 - 6 of 6

Some of the metrics are blocked by your
consent settings
Atangana-Baleanu fractional optimal control for dengue dynamics with stability analysis
(2025-08-01)
Lamwong, Jiraporn
;
Pongsumpun, Puntani
Dengue fever remains a critical public health concern, particularly in regions like Thailand, where the disease exhibits complex transmission dynamics involving human and mosquito populations. Traditional models often fail to address the intricacies of non-local interactions, memory effects, and control dynamics. This research introduces an innovative approach using fractional optimal control problems (FOCPs) integrated with the Atangana-Baleanu fractional derivative in the Caputo sense. The model stratifies human and mosquito populations into detailed compartments, enabling a granular representation of transmission dynamics. The FOCP framework leverages fractional-order equations to incorporate memory-dependent and non-local interactions, ensuring biological feasibility and predictive accuracy. Computational results reveal that the model aligns closely with observed data for dengue fever, dengue hemorrhagic fever, and dengue shock syndrome across fractional orders ranging from 0.83 to 1.00. Sensitivity analyses identify critical parameters, such as biting rates and initial population sizes, as pivotal to disease control. The findings underscore the effectiveness of FOCPs in optimizing public health interventions, offer a robust tool for minimizing infection rates and associated costs. The theoretical global stability analysis confirms the model's reliability in predicting long-term outcomes under varying epidemiological scenarios. Future research could extend this framework to incorporate environmental variables, co-infections, and vaccination strategies, enhancing its applicability across diverse public health challenges. This study represents a significant step forward in the mathematical modeling of epidemic diseases, particularly in optimizing control measures for dengue fever.
Some of the metrics are blocked by your
consent settings
3D-QSAR and molecular docking studies of peptide-hybrids as dengue virus NS2B/NS3 protease inhibitors
(2024-06-01)
Jitonnom, Jitrayut
;
Meelua, Wijitra
;
Tue-nguen, Panthip
;
Saparpakorn, Patchreenart
;
Hannongbua, Supa
Global warming and climate change have made dengue disease a global health issue. More than 50 % of the world's population is at danger of dengue virus (DENV) infection, according to the World Health Organization (WHO). Therefore, a clinically approved dengue fever vaccination and effective treatment are needed. Peptide medication development is new pharmaceutical research. Here we intend to recognize the structural features inhibiting the DENV NS2B/NS3 serine protease for a series of peptide-hybrid inhibitors (R<inf>1</inf>–R<inf>2</inf>-Lys-R<inf>3</inf>-NH<inf>2</inf>) by the 3D-QSAR technique. Comparative molecular field analysis (q2 = 0.613, r2 = 0.938, r2<inf>pred</inf> = 0.820) and comparative molecular similarity indices analysis (q2 = 0.640, r2 = 0.928, r2<inf>pred</inf> = 0.693) were established, revealing minor, electropositive, H-bond acceptor groups at the R<inf>1</inf> position, minor, electropositive, H-bond donor groups at the R<inf>2</inf> position, and bulky, hydrophobic groups at the R<inf>3</inf> position for higher inhibitory activity. Docking studies revealed extensive H-bond and hydrophobic interactions in the binding of tripeptide analogues to the NS2B/NS3 protease. This study provides an insight into the key structural features for the design of peptide-based inhibitors of DENV NS2B/NS3 protease.
Some of the metrics are blocked by your
consent settings
Effect of a Vaccination against the Dengue Fever Epidemic in an Age Structure Population: From the Perspective of the Local and Global Stability Analysis
(2022-03-01)
Chamnan, Anusit
;
Pongsumpun, Puntani
;
Tang, I. Ming
;
Wongvanich, Napasool
The effect of vaccination on the dengue fever epidemic described by an age structured modified SIR (Susceptible-Infected-Retired) model is studied using standard stability analysis. The chimeric yellow fever dengue tetravalent dengue vaccine (CYD-TDV™) is a vaccine recently developed to control this epidemic in several Southeast Asian countries. The dengue vaccination program requires a total of three injections, 6 months apart at 0, 6, and 12 months. The ages of the recipients are nine years and above. In this paper, we analyze the mathematical dynamics SIR transmission model of the epidemic. The stability of the model is established using Routh–Hurwitz criteria to see if a Hopf Bifurcation occurs and see when the equilibrium states are local asymptotically stable or global asymptotically stable. We have determined the efficiency of CYD-TDV by simulating the optimal numerical solution for each age range for this model. The numerical results showed the optimal age for vaccination and significantly reduced the severity and severity of the disease.
Some of the metrics are blocked by your
consent settings
Local and global stability analysis of dengue disease with vaccination and optimal control
(2021-10-01)
Chamnan, Anusit
;
Pongsumpun, Puntani
;
Tang, I. Ming
;
Wongvanich, Napasool
Dengue fever is a disease that has spread all over the world, including Thailand. Dengue is caused by a virus and there are four distinct serotypes of the virus that cause dengue DENV‐1, DENV‐2, DENV‐3, and DENV‐4. The dengue viruses are transmitted by two species of the Aedes mosquitoes, the Aedes aegypti, and the Aedes albopictus. Currently, the dengue vaccine used in Thailand is chimeric yellow tetravalent dengue (CYD‐TDV). This research presents optimal control which studies the vaccination only in individuals with a documented past dengue infection (seropositive), regardless of the serotypes of infection causing the initial infection by the disease. The analysis of dengue transmission model is used to establish the local asymptotically stabilities. The property of symmetry in the Lyapunov function an import role in achieving this global asymptotically stabilities. The optimal control systems are shown in numerical solutions and conclusions. The result shows that the control resulted in a significant reduction in the number of infected humans and infected vectors.
Some of the metrics are blocked by your
consent settings
Optimal control of the dengue dynamical transmission with vertical transmission
(2019-12-01)
Pongsumpun, Puntani
;
Tang, I. Ming
;
Wongvanich, Napasool
Dengue disease is found in tropical and subtropical regions around the world. Dengue virus is the cause of dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. It consists of 4 serotypes: DEN-1, DEN-2, DEN-3, and DEN-4. There are two modes of transmission for dengue virus in mosquito: horizontal transmission and vertical transmission. The mosquito can be infected when it bites an infectious human by horizontal transmission, but there can also be vertical transmission through sexual contact with an infected mosquito. This research presents a control mechanism based on our previously developed dengue model with vertical transmission. The two policies, namely vaccination and insecticide administration (Policy 1) and isolation and insecticide administration (Policy 2) are considered. The use of Pontryargin’s maximum principle allowed necessary and optimality conditions, thus facilitating the optimal control to be developed. Numerical solutions of our control systems and the conclusions of our two policies are presented.
Some of the metrics are blocked by your
consent settings
Association between circulating cortisol and ACTH and severity of dengue infection in adult patients
(2019-01-01)
Sura-Amornkul, S.
;
Pitabut, N.
;
Pholtawornkulchai, K.
;
Matangkasombut, P.
;
Sakuntabhai, A.
Objective: To study the kinetics of endocrine changes in adult patients with dengue hemorrhagic fever (DHF) and dengue fever (DF) and association to disease severity. Materials and Methods: This hospital-based observational clinical study involved 48 adult patients, 32 with DHF and 16 with DF, who presented with clinical features and positive serological testing for dengue infection on the day of diagnosis (D1). Serial circulating ACTH and cortisol concentrations were determined on D1, day of defervescence (Ddef), day 1 of convalescence (DC1 or 24 h after Ddef), day 2 of convalescence (DC2 or 48 h after Ddef), at 2-week follow-up (F1), and 2-month follow-up (F2). Results: The median cortisol concentration in the DHF group was higher on D1 than that at F2. This was not found in patients with DF who had no difference of median cortisol concentration at D1 and F2. The median ACTH concentrations in both DHF and DF groups were low on D1 and trended toward recovery at F2. There was association between circulating ACTH and cortisol concentrations at D1 in patients with the severity of DHF (r = 0.309, p = 0.042) but not of DF. Conclusion: The ACTH and cortisol responses were associated with severity of dengue infection and recovery after 2 months.

KMITL

Browse

Filters

Settings

Sort By

Results per page

Search Results