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Author: search.filters.author.Tang, I. MingSubject: search.filters.subject.Optimal control

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    Mathematical modeling and optimal control of the hand foot mouth disease affected by regional residency in Thailand
    (2021-11-01)
    Wongvanich, Napasool
    ;
    Tang, I. Ming
    ;
    Dubois, Marc Antoine
    ;
    Pongsumpun, Puntani
    Hand, foot and mouth disease (HFMD) is a virulent disease most commonly found in East and Southeast Asia. Symptoms include ulcers or sores, inside or around the mouth. In this research, we formulate the dynamic model of HFMD by using the SEIQR model. We separated the infection episodes where there is a higher outbreak and a lower outbreak of the disease associated with regional residency, with the higher level of outbreak occurring in the urban region, and a lower outbreak level occurring in the rural region. We developed two different optimal control programs for the types of outbreaks. Optimal Control Policy 1 (OPC1) is limited to the use of treatment only, whereas Optimal Control Policy 2 (OPC2) includes vaccination along with the treatment. The Pontryagin’s maximum principle is used to establish the necessary and optimal conditions for the two policies. Numerical solutions are presented along with numerical sensitivity analyses of the required control efforts needed as the control parameters are changed. Results show that the time t<inf>max</inf> required for the optimal control effort to stay at the maximum amount u<inf>max</inf> exhibits an intrinsic logarithmic relationship with respect to the control parameters.
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    Local and global stability analysis of dengue disease with vaccination and optimal control
    (2021-10-01)
    Chamnan, Anusit
    ;
    Pongsumpun, Puntani
    ;
    Tang, I. Ming
    ;
    Wongvanich, Napasool
    Dengue fever is a disease that has spread all over the world, including Thailand. Dengue is caused by a virus and there are four distinct serotypes of the virus that cause dengue DENV‐1, DENV‐2, DENV‐3, and DENV‐4. The dengue viruses are transmitted by two species of the Aedes mosquitoes, the Aedes aegypti, and the Aedes albopictus. Currently, the dengue vaccine used in Thailand is chimeric yellow tetravalent dengue (CYD‐TDV). This research presents optimal control which studies the vaccination only in individuals with a documented past dengue infection (seropositive), regardless of the serotypes of infection causing the initial infection by the disease. The analysis of dengue transmission model is used to establish the local asymptotically stabilities. The property of symmetry in the Lyapunov function an import role in achieving this global asymptotically stabilities. The optimal control systems are shown in numerical solutions and conclusions. The result shows that the control resulted in a significant reduction in the number of infected humans and infected vectors.
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    Optimal control of dengue transmission with vaccination
    (2021-08-01)
    Chamnan, Anusit
    ;
    Pongsumpun, Puntani
    ;
    Tang, I. Ming
    ;
    Wongvanich, Napasool
    Dengue disease is caused by four serotypes of the dengue virus: DEN-1, DEN-2, DEN-3, and DEN-4. The chimeric yellow fever dengue tetravalent dengue vaccine (CYD-TDV) is a vaccine currently used in Thailand. This research investigates what the optimal control is when only individuals having documented past dengue infection history are vaccinated. This is the present practice in Thailand and is the latest recommendation of the WHO. The model used is the Susceptible-Infected-Recovered (SIR) model in series configuration for the human population and the Susceptible-Infected (SI) model for the vector population. Both dynamical models for the two populations were recast as optimal control problems with two optimal control parameters. The analysis showed that the equilibrium states were locally asymptotically stable. The numerical solution of the control systems and conclusions are presented.
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    Optimal control of the dengue dynamical transmission with vertical transmission
    (2019-12-01)
    Pongsumpun, Puntani
    ;
    Tang, I. Ming
    ;
    Wongvanich, Napasool
    Dengue disease is found in tropical and subtropical regions around the world. Dengue virus is the cause of dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. It consists of 4 serotypes: DEN-1, DEN-2, DEN-3, and DEN-4. There are two modes of transmission for dengue virus in mosquito: horizontal transmission and vertical transmission. The mosquito can be infected when it bites an infectious human by horizontal transmission, but there can also be vertical transmission through sexual contact with an infected mosquito. This research presents a control mechanism based on our previously developed dengue model with vertical transmission. The two policies, namely vaccination and insecticide administration (Policy 1) and isolation and insecticide administration (Policy 2) are considered. The use of Pontryargin’s maximum principle allowed necessary and optimality conditions, thus facilitating the optimal control to be developed. Numerical solutions of our control systems and the conclusions of our two policies are presented.