Sontigun, Narin

Loading...
Thumbnail Image
Preferred name
Sontigun, Narin
Main Affiliation
Email
narin.so@kmitl.ac.th

Settings

Now showing 1 - 2 of 2
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Improvements in Blood Profiles of Canines Naturally Infected with Triple Blood Pathogens (Babesia vogeli, Ehrlichia canis, and Anaplasma platys) Subsequent to Doxycycline Monotherapy
    (2024-12-01)
    Wongtawan, Tuempong
    ;
    Sontigun, Narin
    ;
    Boonchuay, Kanpapat
    ;
    Chiawwit, Phatcharaporn
    ;
    Wongtawan, Oraphan
    Multiple blood pathogen infections are increasingly found in many areas, particularly in tropical regions. This study aimed to investigate the effectiveness and safety of using doxycycline monotherapy to treat triple blood pathogen infection in sheltered dogs. A total of 375 sheltered dogs were screened for blood pathogen using polymerase chain reaction technique (PCR). There were 34 dogs with triple infection (Babesia vogeli, Ehrlichia canis, and Anaplasma platys), and most dogs displayed anemia and thrombocytopenia. These dogs were treated with doxycycline (10 mg/kg/day) orally for four weeks, and their blood profiles were monitored. Almost all pathogens were undetectable by PCR by day 14 and pathogens were all cleared by day 28. Most blood profiles significantly improved after 14 days. The improvement continued after 28 days. The red blood cell and platelet count (PLT) were increased in similar trends between mild-to-moderate and severe thrombocytopenia groups. The average PLT in the mild-to-moderate thrombocytopenia group raised to normal level by day 14, whereas in the severe group, it was gradually increased to normal level by day 70. We propose using doxycycline monotherapy for 28 days to eliminate all pathogens, and facilitate recovery and welfare in dogs suffering with triple blood pathogen infections.
  • Loading...
    Thumbnail Image
    Some of the metrics are blocked by your 
    consent settings
    Item type:Publication,
    Age-related comparative study of C-reactive protein, lipid profile biomarkers, and strongyle nematode gastrointestinal parasitic burden in horses
    (2026-10-01)
    Phetkarl, Tanakorn
    ;
    Sontigun, Narin
    ;
    Boonchuay, Kanpapat
    ;
    Sansamur, Chalutwan
    ;
    Semmarath, Warathit
    Background Gastrointestinal (GI) parasitic infection remains one of the most prevalent and economically significant health challenges in equine populations. The infective stages of GI parasites can activate systemic inflammatory responses and disrupt lipid metabolism leading to exacerbation of parasitic infection. Moreover, age-related low-grade chronic inflammation may further contribute to the persistent infection which impacts the health status of individual horses. Aims/Objective This study examined serum levels of the inflammatory marker C-reactive protein (CRP) and lipid profile parameters to identify age-related patterns in horses in the high prevalence area of GI parasitic infection in Southern Thailand. Methods Seventy-seven horses were categorized into four age groups: foal (<1 year); young (1–3.99 years); early adult (4–10 years); and late adult (>10 years) and were examined for fecal helminth eggs and fecal egg count (EPG) using a modified McMaster technique. The serum CRP, and lipid profile parameters including total cholesterol (TC), total triglyceride (TG), high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C), LDL: HDL, and TC:HDL ratios were determined. Results Strongyle nematodes, including cyathostomins and Strongylus vulgaris were detected with the prevalence >60% of horses across all age groups. CRP, TC, and LDL-C levels increased significantly with age (p < 0.01), while HDL-C levels significantly declined in the late adult group when compared with other age groups (p = 0.0037). Among all age groups of horses, Spearman correlation (ρ) and binary logistic regression (odd ratio: OR [95%CI]) revealed that serum CRP, and LDL-C levels were positively associated with the EPG of strongyle nematode helminths. While HDL-C levels showed negative correlation. CRP, LDL: HDL, and TC:HDL ratios were identified as the risk factors for strongyle nematode GI infection. Using the ROC analysis, the cut-off values of CRP (>0.49 mg/L; %sensitivity [SS] = 72.97, %specificity [SP] =75.00), LDL: HDL (>2.476; %SS=64.29, %SP=71.43), and TC: HDL (>5.198; %SS=51.22, %SP=83.33%) could help predict the strongyle nematode GI parasitic infection in horses. Conclusions These findings highlight the diagnostic potential of CRP and cholesterol index as the prognostic biomarkers and disease monitoring in equine strongyle nematode infection to provide the proper management and intervention to current parasite management strategies.
      1