Chotsaeng, Nawasit
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Item type:Publication, DBU-Mediated Dimerization: Facile Access to 9,9′-Bifluorenylidenes and Isoindigos(2023-11-14); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Oxidative damage in Echinochloa crus−galli seeds exposed to Diaporthe sp. (Diaporthales, Ascomycota) fungal extract during germination(2024-01-01); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Ultrasonic emulsification of Cananga odorata nanoemulsion formulation for enhancement of herbicidal potential(2025-12-01); ; ; A nanoemulsion was fabricated from Cananga odorata essential oil (EO) and stabilized by incorporation of Tween 80 using ultrasonication. The major constituents of the EO were benzyl benzoate, linalool, and phenylmethyl ester. Differing sonication amplitude (20–60%) and time (2–10 min) were assessed for effects on nanoemulsion droplet size and polydispersity index (PI). The smallest droplet size of 43.98 nm (PI 0.222) was obtained using 40% amplitude for 8 min; this nanoemulsion was evaluated for its droplet characteristics and pre-emergence herbicidal activities on Amaranthus tricolor. FT-IR confirmed ultrasonic emulsification to not affect the EO components. Regarding stability, storage at 4 °C was determined appropriate, with droplet size changing slightly after five weeks. Assays of herbicidal potential showed the coarse emulsion and nanoemulsion to both reduce A. tricolor germination and growth, with the nanoemulsion being more effective at a given concentration and the difference in effectivity correlating to droplet size. Remarkably, treatment with 250 ppm nanoemulsion and coarse emulsion respectively resulted in 100% and 63.75% germination inhibition. Both emulsions decreased seed imbibition and alpha-amylase activity. The highest relative electrolyte leakage was achieved in seed treated with the nanoemulsion. Therefore, this ultrasonic-based nanoemulsion may have utility as bioherbicide alternative. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, High-Energy Emulsified Clove Essential Oil Nanoemulsion as a Natural Herbicidal Product: Germination Suppression and Seed Structure Alteration in Echinochloa crus-galli(2026-03-01); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, DBU-Mediated Reaction of 3-Chlorooxindole and 9-Xanthyl Fluorene for Synthesis of 3-Arylidene Oxindole(2025-04-01); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Citronella essential oil-based nanoemulsion as a post-emergence natural herbicide(2023-12-01); ; ; A natural herbicide nanoemulsion was fabricated from citronella (Cymbopogon nardus L.) essential oil (CEO) and a nonionic surfactant Tween 60 mixed with Span 60 at hydrophilic-lipophilic balance 14 using a microfluidization method. The main constituents of CEO were citronellol (35.244%), geraniol (21.906%), and citronellal (13.632%). CEO nanoemulsion droplet size and polydispersity index (PI) were evaluated by dynamic light scattering (DLS). The smallest droplet size (33.2 nm, PI 0.135) was obtained from a microfluidizer at 20,000 psi, 7 cycles. Nanoemulsion droplet in transmission electron microscopy correlated with DLS confirmed CEO to successfully produce nanoemulsion. The herbicidal activity of the nanoemulsion as a foliar spray was evaluated against Echinochloa cruss-galli and Amaranthus tricolor as representative narrow- and broadleaf weed plants, both of which presented visual toxicity symptoms. The modes of action of the nanoemulsion were then determined in terms of membrane integrity (relative electrolyte leakage; REL), malondialdehyde (MDA), and photosynthetic pigment contents. The results showed increase in REL and MDA which indicated the destruction of the treated plants; additionally, chlorophylls and carotenoid contents were decreased. Consequently, CEO nanoemulsion may have the possibility to act as a natural herbicide resource, and natural herbicides from citronella nanoemulsions could be good alternatives for use in sustainable agriculture. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Bioassay-Guided Extraction and Isolation of Natural Herbicides from Dried Zanthoxylum limonella Alston Fruits(2025-01-01); ; ; ; Jongkon, NathjananWeeds are problematic plant species around the world. Various strategies exist for controlling weeds, but chemical treatment remains the preferred method, particularly when using natural substances. In this research, a crude aqueous-methanol extract from dried Zanthoxylum limonella fruits was acid-base partitioned into four fractions: neutral extract (NE), acid extract (AE), basic extract (BE), and aqueous extract (AQ). These fractions were further separated into seventeen subfractions: NEF1 to NEF7, AEF1 to AEF5, and BEF1 to BEF5, which were then tested for herbicidal activity against the growth of Chinese amaranth (Amaranthus tricolor) and barnyard grass (Echinochloa crus-galli). Active subfractions were isolated via column chromatography and identified using spectroscopic methods, yielding seven active compounds: xanthoxyline (1), tambulin (2), atanine (3), prudomestin (4), skimmianine (5), p-methoxybenzoic acid (6), and methyl caffeate (7). Compounds 2–7 had not been previously reported in Z. limonella. Xanthoxyline (1) was identified as the most potent botanical herbicide, fully inhibiting seed germination of Chinese amaranth and barnyard grass. This compound also decreased seed imbibition and α-amylase activity in both species. Molecular docking studies on the α-amylase enzyme (PDB ID: 1BG9) revealed that the aromatic, hydroxy, and carbonyl groups of xanthoxyline (1) interact with the enzyme's active sites. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Synthesis and Cytotoxicity Evaluation of Novel C-3 Aminocarbamate Pregnenolone Derivatives(2025-03-06); Cancer is one of the leading causes of death worldwide. There are many ongoing studies in the search for new treatments or drugs to combat cancer. Similarly, in this research, twelve 3-aminocarbamate pregnenolones (2a–2l) were designed, synthesized, and evaluated for their cytotoxicity against five cancer cell lines: Human hepatocellular carcinoma (HepG2), Human colon adenocarcinoma (HT-29), Human oral cavity carcinoma (KB), Human breast adenocarcinoma (MCF-7), Murine leukemia (P388), and one normal cell line, African green monkey kidney fibroblast (Vero), using the MTT assay. Notably, 3-aminobenzylcarbamate pregnenolone (2b), 3-diaminoheptylcarbamate pregnenolone (2f), and 3-diaminopropanolcarbamate derivative (2i) were the most potent against these cancer cell lines. Specifically, for P388 cell lines, these compounds were more potent than the positive control drug, vinblastine sulfate salt. Results from the SAR study demonstrated that the length of the alkyl chain of diaminocarbamate derivatives was crucial for their anticancer properties. These findings will be useful in the future research and development of anticancer drugs. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Design, Synthesis, and Herbicidal Activity of Novel Dihydrochalcones Derived from Flavokawains and Their Analogs(2026-05-01); ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Synthesis of pyrimidines from flavokavains and their 2′-hydroxychalcone analogues(2026-01-01); Pyrimidines are an important class of heterocycles with diverse biological activities; however, their synthesis from certain substrates remains challenging. In this work, flavokavains and their derivatives were converted into pyrimidines, although initial reactions under basic conditions gave low yields due to a competing intramolecular isomerization to flavanones. Systematic investigation identified solvent as a key factor, with 1,4-dioxane effectively suppressing flavanone formation and enabling the synthesis of a broad range of pyrimidines in moderate to high yields. Both guanidine and benzamidine served as effective nucleophiles, and the reaction was readily scalable to the gram scale. This protocol provides a practical and efficient route to ortho-hydroxyphenyl-substituted pyrimidines, which may serve as useful scaffolds for medicinal chemistry.