Jiraanont, Poonnada

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Jiraanont, Poonnada
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Email
poonnada.ji@kmitl.ac.th

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    Item type:Publication,
    Acceptance and attitudes towards carrier and prenatal screening for fragile X syndrome among reproductive-aged Thai women: a cross-sectional study
    (2026-01-01)
    Tassanakijpanich, Nattaporn
    ;
    Chumchuen, Kemmapon
    ;
    Panpaprai, Pacharee
    ;
    Iamurairat, Wiwat
    ;
    Chutimongkonkul, Wiboon
    Objectives: Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability, but Thailand lacks a carrier screening programme. We assessed knowledge, attitudes, and acceptance of FXS carrier and prenatal screening among reproductive-aged Thai women, exploring socio-demographic correlates. Methods: This study was conducted at a drop-in clinic, Department of Obstetrics and Gynecology of a Tertiary Hospital, where eligible women watched a 3-min educational video, and then completed a questionnaire evaluating knowledge, screening acceptance, and four attitude domains (disclosure, policy, relationship, pregnancy continuation). Ordinal logistic regression analysed socio-demographic associations. Results: Post-video, 87% of 772 women understood FXS well. Acceptance was substantial: 82% for carrier screening and 95% for prenatal investigation. Higher education was associated with greater knowledge (adjusted odds ratio [aOR] = 1.66, 95% confidence interval [CI]: 1.23–2.23) and policy support (aOR = 1.83, 95% CI: 1.35–2.48). Older age was associated with lower knowledge (aOR = 0.98, 95% CI: 0.96–1.00), disclosure intent (aOR = 0.98, 95% CI: 0.96–1.00), and agreement in continuing an affected pregnancy (aOR = 0.97, 95% CI: 0.95–0.99). Conclusion: Brief educational interventions can support informed acceptance of FXS screening. To support the diverse reproductive options, Thailand should implement publicly funded voluntary screening with culturally sensitive genetic counselling.