Paiboon, Narin

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Paiboon, Narin
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Email
narin.pa@kmitl.ac.th

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    Item type:Publication,
    Inclusion complex of water-soluble arbutin with β-cyclodextrin: Computer modeling and experimental studies
    (2025-03-01)
    Paiboon, Narin
    ;
    Rujipairoj, Supawan
    ;
    Surassmo, Suvimol
    ;
    Ruktanonchai, Uracha Rungsardthong
    ;
    Phunpee, Sarunya
    A water-soluble arbutin was investigated for its potential to form an inclusion complex with β-cyclodextrin (β-CD). Molecular modeling tests confirmed that arbutin can be accommodated within the cavity of β-CD primarily through Van der Waals forces rather than electrostatic interactions. The structure of the arbutin-β-CD inclusion complex was characterized using Differential Scanning Calorimetry (DSC), and Proton Nuclear Magnetic Resonance Spectroscopy (<sup>1</sup>H NMR). The inclusion complex prepared at a mole ratio of 1:1 (arbutin: β-CD) exhibited the highest encapsulation efficiency at 43.72 %. The study findings affirm that encapsulation of arbutin within β-CD does not reduce its inherent antioxidant activity and its inhibitory effects against tyrosinase enzyme activity. Moreover, the complexation of arbutin with β-CD resulted in a notably slower release rate, indicating the role of β-CD in modulating substance release kinetics. Furthermore, encapsulation of arbutin within β-CD demonstrated a reduction in hydrolysis from arbutin to hydroquinone by Staphylococcus epidermidis, highlighting the potential of the inclusion complex to mitigate enzymatic conversion processes.
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    Item type:Publication,
    Synthesis of Cyclodextrin-Grafted Chitosan: From Laboratory Scale to Pilot Scale
    (2023-12-15)
    Paiboon, Narin
    ;
    Phunpee, Sarunya
    ;
    Ruktanonchai, Uracha Rungsardthong
    ;
    Surassmo, Suvimol
    ;
    Methaapanon, Rungthiwa
    The CD-g-CS complex particle, made from the synthesis of toluenesulfonyl β-cyclodextrin (TsCD) and chitosan (CS), has a wide range of applications. Previous laboratory studies have proven the feasibility of the synthesis process, but larger-scale studies are necessary for wide utilization. This study aimed to scale up the reaction process from a 250 mL laboratory scale to 2, 10, and 500 L batch stirred-tank reactors, using a stepwise approach. Factors such as the mole ratio of TsCD to CS, reaction temperature, and reaction time were studied to optimize the synthesis. The degree of N-substitution (DS) was used to assess the number of grafted TsCD per primary amino group of chitosan, which is the key measure of the high-quality CD-g-CS. The results indicated that the DS increased with the increasing TsCD to CS mole ratio and reached a maximum at a reaction temperature of 95 °C. The reaction reached optimum results after 24 h. The constant heat transfer rate per unit volume was used as a successful scaling factor for the 10 and 500 L CD-g-CS processes.