Prachayawarakorn, Jutarat

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Preferred name
Prachayawarakorn, Jutarat
Alternative Name
Prachayawarakorn, J.
Main Affiliation
Email
jutarat.si@kmitl.ac.th

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    Item type:Publication,
    Asymmetric dot-patterned wettable and antibacterial wound dressings from bacterial cellulose–alginate composites coated with stearic acid-modified ZnO/chitosan/AgNPs
    (2025-01-01)
    Ieamviteevanich, Pimchanok
    ;
    Onklam, Panida
    ;
    Kampechdee, Wariya
    ;
    Churiwan, Achana
    ;
    Vittayakorn, Naratip
    To improve the wound dressing characteristics of bacterial cellulose-based materials and address the issue of asymmetric wound dressing with one hydrophilic side and another hydrophobic side, this study developed a new concept for the fabrication of an asymmetric wettable and antibacterial wound dressing by selective drop coating of stearic acid-modified ZnO, chitosan, and AgNPs to form a dot pattern on both surfaces of a bacterial cellulose–alginate composite (BA-ZnS/Ch/Ag). The coated surface was hydrophobic, with a WCA of 150° due to the formation of a low surface energy zinc stearate (C<inf>17</inf>H<inf>35</inf>COO)<inf>2</inf>Zn) monolayer on the ZnO particles and a high degree of hierarchical roughness. The asymmetric wettable BA-ZnS/Ch/Ag wound dressing maintained good water absorptivity (swelling rate 417%) and natural breathability (water vapor transmission rate 792 g.m<sup>−2</sup> day<sup>−1</sup>) of the superhydrophilic bacterial cellulose-alginate composite that consisted of dense outer surfaces and porous inner layers and simultaneously possessed the superhydrophobic property of the coating area that can reduce the risk of infection from external fluids and improve the blood repellency and anti-adhesion properties. The BA-ZnS/Ch/Ag wound dressing showed good antibacterial activity against S. aureus and E. coli and non-toxicity to human keratinocyte immortal cells (HaCaT), making it suitable for clinical applications.
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    Property improvement of antibacterial wound dressing from basil seed (O. basilicum L.) mucilage- ZnO nanocomposite by borax crosslinking
    (2020-01-01)
    Tantiwatcharothai, Siriporn
    ;
    Prachayawarakorn, Jutarat
    Some applications, in particular, wound dressings, require significant water holding capability: hydrogels formed from Basil seed mucilage (BSM) are non-toxic natural substances and exhibit the needed water holding capacity. However, the sponges have low dimensional stability and easily degrade in aqueous media. We overcame this drawback by crosslinking with borax. To provide antibacterial activity, zinc oxide nanoparticles (ZnO-NP) were added. With 10–20 wt% added borax and ZnO-NP, all key properties improved: dimensional stability, water retention capacity (31 to 41%), stress at maximum load (2.6 to 6.6 MPa), Young's modulus (74 to 113 MPa) and strain (28 to 54%). An interconnecting system of pores with well distributed ZnO-NP was observed from scanning electron microscope. In addition, higher borax and ZnO-NP loadings slightly decreased porosity (92% to 73%) and swelling (109 to 56). Moreover, antibacterial activity and cytotoxicity of BSM hydrogel sponge were also examined.