Locharoenrat, Kitsakorn

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Locharoenrat, Kitsakorn
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LOCHAROENRAT, KITSAKORN
Locharoenrat, K.
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Email
kitsakorn.lo@kmitl.ac.th

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    Item type:Publication,
    Simulation of copper thin film thickness optimization for surface plasmon using the finite element method
    (2017-01-01)
    Leelawattananon, Tanaporn
    ;
    Locharoenrat, Kitsakorn
    ;
    Chittayasothorn, Suphamit
    This paper presents a computer simulation of optical activations based on the Kretschmann configuration using a prism for the observation of the surface plasmon wave. This is according to the condition of the dispersion relation. The analysis of the electric field of the surface plasmon wave which appears at the interface between the metal layer and the air layer is done by using the Finite Element Method (FEM). The simulation is performed using the COMSOL Multiphysics software which supports the FEM. The objective of our experiment is to find the most suitable thickness of the metal thin film which is most suitable for the surface plasmon excitation when activated by 632.5 nm red laser light source. The red laser light source is commonly available and also very economical. The metal used in our work is copper which is an economical noble metal and gives better conductivity than gold. The findings from the simulation will be used in the future high precision physical experiments. The outcome of this research project, the surface plasmon wave on copper thin film, is expected to be used in bio-molecular detectors or high speed THz communications.
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    Antitumor activities of carboplatin–doxorubicin–ZnO complexes in different human cancer cell lines (breast, cervix uteri, colon, liver and oral) under UV exposition
    (2021-01-01)
    Pairoj, Suttirak
    ;
    Damrongsak, Pattareeya
    ;
    Damrongsak, Badin
    ;
    Jinawath, Natini
    ;
    Kaewkhaw, Rossukon
    This study aimed to examine the pharmacological profiles of multiple chemo drug candidates in systematic circulation to enhance their specific interactions with five human cancer cell lines. ZnO nanoparticles were successfully bound with chemo drugs via physical adsorption. The drug loading capacity was confirmed by FTIR, whereas the loading efficiency was determined via UV–vis spectrometry. The mean hydrodynamic size increased to 69–82 nm after chemo-drug immobilization via non-covalent interaction with ZnO. Among the nine formulated chemo drugs, the carboplatin (CP)–doxorubicin (DOX)–ZnO complex under UV light irradiation exhibited high sensitivity towards human breast adenocarcinoma cells without affecting human keratinocyte immortal cells with an IC<inf>50</inf> of 0.137 µg/mL, whereas the loading capacity and efficiency of CP–DOX–ZnO were 77.81% and 99.05%, respectively. Fluorescence images confirmed that CP–DOX–ZnO using DOX served as a fluorescence enhancer specifically bound onto the cell membranes, which became almost saturated after 24 h incubation. Carboplatin–DOX–ZnO was possibly endocytosed by cancer cells and was selectively internalized into the target cells; thus, free chemo drug was released in the cytoplasm, which induced acute apoptosis. This resulted in complete inhabitation of growth signal of target cancer cells.
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    Antiradical properties of chemo drug, carboplatin, in cooperation with ZnO nanoparticles under UV irradiation in putative model of cancer cells
    (2019-07-01)
    Pairoj, Suttirak
    ;
    Damrongsak, Pattareeya
    ;
    Damrongsak, Badin
    ;
    Jinawath, Natini
    ;
    Kaewkhaw, Rossukon
    The main objective of this study was to assess the antiradical properties of zinc oxide (ZnO) nanoparticles upon exposure to ultraviolet radiation with carboplatin, an anti-proliferative drug used in the treatment of retinoblastoma. For the purpose of this study, the decomposition of 2,2(diphenyl-1-picryhydrazyl) radical (DPPH*) was used to assess the free radical capacity of antioxidants and was followed by MTT measurements. To test the antiradical capacity, the effective concentration, antiradical power, stoichiometry, and number of reduced DPPH* were investigated. DPPH* has a peak absorbance at a wavelength of 515 nm, which disappears upon the introduction of the antiradical agents. Four agents were reacted with DPPH* and represented the possible reaction kinetic categories. ZnO nanoparticles and carboplatin-loaded ZnO nanoparticles reacted more strongly with DPPH* and approached a saturation state at 420 min. The remaining two antiradical agents, ZnO nanoparticles under UV radiation and carboplatin-loaded ZnO nanoparticles under UV radiation, reacted a bit slower with DPPH* and approached a steady state at 1440 min. Among the different four antiradical agents, carboplatin-loaded ZnO nanoparticles under UV light had the highest antiradical response with the lowest effective concentration value to the reduced DPPH* molecules. ZnO nanoparticles alone were found to be poor antiradical agent. Possible mechanisms were attributed to the number of hydroxyl groups available to decrease the number of DPPH*.
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