Leelawattananon, Tanaporn

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Preferred name
Leelawattananon, Tanaporn
Alternative Name
Leelawattananon, Thanaporn
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Email
tanaporn.le@kmitl.ac.th

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    Antitumor activities of carboplatin–doxorubicin–ZnO complexes in different human cancer cell lines (breast, cervix uteri, colon, liver and oral) under UV exposition
    (2021-01-01)
    Pairoj, Suttirak
    ;
    Damrongsak, Pattareeya
    ;
    Damrongsak, Badin
    ;
    Jinawath, Natini
    ;
    Kaewkhaw, Rossukon
    This study aimed to examine the pharmacological profiles of multiple chemo drug candidates in systematic circulation to enhance their specific interactions with five human cancer cell lines. ZnO nanoparticles were successfully bound with chemo drugs via physical adsorption. The drug loading capacity was confirmed by FTIR, whereas the loading efficiency was determined via UV–vis spectrometry. The mean hydrodynamic size increased to 69–82 nm after chemo-drug immobilization via non-covalent interaction with ZnO. Among the nine formulated chemo drugs, the carboplatin (CP)–doxorubicin (DOX)–ZnO complex under UV light irradiation exhibited high sensitivity towards human breast adenocarcinoma cells without affecting human keratinocyte immortal cells with an IC<inf>50</inf> of 0.137 µg/mL, whereas the loading capacity and efficiency of CP–DOX–ZnO were 77.81% and 99.05%, respectively. Fluorescence images confirmed that CP–DOX–ZnO using DOX served as a fluorescence enhancer specifically bound onto the cell membranes, which became almost saturated after 24 h incubation. Carboplatin–DOX–ZnO was possibly endocytosed by cancer cells and was selectively internalized into the target cells; thus, free chemo drug was released in the cytoplasm, which induced acute apoptosis. This resulted in complete inhabitation of growth signal of target cancer cells.
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    A Mobile Application for Electronic Parts Counting and Identification in Physics Laboratory
    (2025-01-01)
    Leelawattananon, Tanaporn
    ;
    Chittayasothorn, Suphamit
    Counting of small objects such as resistors, capacitors, and inductors in physics laboratories are tedious and challenging tasks because of their numbers and small size. In this paper we present the development of a mobile application for counting and identifying small electronics parts. The system employs object edges detection using the difference of gaussian operator and classify the objects using template matching. Pictures taken using mobile phone camera are used as the input to the mobile application which correctly classify and count the objects. Electronics objects used in the counting and classification include resistors, mylar capacitors, and ceramic capacitors. The mobile application helps reduce the work required by laboratory personnel for intermediate physics laboratory management and is now deployed in the physics laboratory of the School of Science, King Mongkut's Institute of Technology Ladkrabang.
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    Electronic Parts Counting in Physics Laboratory Using Difference of Gaussians Edge Extraction
    (2024-01-01)
    Leelawattananon, Tanaporn
    ;
    Chittayasothorn, Suphamit
    Small electronic parts counting in the physics laboratory is a challenging task. These small objects such as resistors, capacitors, and inductors are used in physics laboratories and because of their numbers and small size, are hard to count in a short period of time. The precise inventory of these small electronics parts is therefore compromised. In this paper we present the development of a small electronics parts counting system. The system employs object edges detection using the difference of gaussian operator. This technique is suitable for those small electronic objects which have clear boundaries. By adjusting relevant parameters sigma and threshold to suit the size of the objects, the edge images are clearly detected thus enable correct counting of the objects which leads to correct inventory of electronics parts. An alternative technique using the canny edge detector operator is also used as a comparison technique. The experimental results are precise.