Choengchan, Nathawut

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Choengchan, Nathawut
Alternative Name
Choengchan, N.
Choengchan, Nuthawut
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Email
nathawut.ch@kmitl.ac.th

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    Item type:Publication,
    A Novel Cross Injection Analysis for Simultaneous Multi-Determination of Diabetic Nephropathy Biomarkers in Urine
    (2026-05-01)
    Inpota, Prawpan
    ;
    Choengchan, Nathawut
    This work presents, for the first time, a novel cross injection analysis (CIA) system for the simultaneous multi-determination of key biomarkers associated with diabetic nephropathy—namely, albumin, creatinine, and glucose—within a single analytical run. Unlike conventional flow-based techniques that rely on sequential measurements, the proposed CIA platform integrates multiple analytical pathways into a unified design, enabling one-shot multi-analyte analysis without the need for complex separation units or injection valves. The system employs peristaltic pumps and a rectangular platform with orthogonal flow channels, allowing concurrent aspiration and efficient transport of reaction products to compact detectors. Albumin determination was based on ion-association with tetrabromophenolphthalein ethyl ester. Creatinine was measured using the Jaffé reaction. Glucose was colorimetrically detected via its reaction with 3,5-dinitrosalicylic acid. The developed CIA provides enhanced sensitivity through its pre-mixing effect, enabling reliable quantification of trace analytes. Excellent analytical performance was achieved, including wide linear ranges (r<sup>2</sup> > 0.99), good precision (RSD < 7%), and rapid analysis (5 min). The method was validated against established reference methods, showing no significant differences, and successfully applied to urine with satisfactory recoveries (84.8–107.3%). Importantly, the proposed system adheres to green chemistry by minimizing reagent consumption and waste generation, offering a sustainable approach for multi-parameter clinical analysis.
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    Item type:Publication,
    Transparent Cross-Flow Platform as Chemiluminescence Detection Cell in Cross Injection Analysis
    (2023-02-01)
    Somboonsuk, Thachkorn
    ;
    Saetear, Phoonthawee
    ;
    Mantim, Thitirat
    ;
    Ratanawimarnwong, Nuanlaor
    ;
    Wilairat, Prapin
    This work presents the use of a transparent ‘Cross Injection Analysis’ (CIA) platform as a flow system for chemiluminescence (CL) measurements. The CL-CIA flow device incorporates introduction channels for samples and reagents, and the reaction and detection channels are in one acrylic unit. A photomultiplier tube placed above the reaction channel detects the emitted luminescence. The system was applied to the analysis of (i) Co(II) via the Co(II)-catalyzed H<inf>2</inf>O<inf>2</inf>-luminol reaction and (ii) paracetamol via its inhibitory effect on the catalytic activity of Fe(CN)<inf>6</inf><sup>3−</sup> on the H<inf>2</inf>O<inf>2</inf>-luminol reaction. A linear calibration was obtained for Co(II) in the range of 0.002 to 0.025 mg L<sup>−1</sup> Co(II) (r<sup>2</sup> = 0.9977) for the determination of Co(II) in water samples. The linear calibration obtained for the paracetamol was 10 to 200 mg L<sup>−1</sup> (r<sup>2</sup> = 0.9906) for the determination of pharmaceutical products. The sample throughput was 60 samples h<sup>−1</sup>. The precision was ≤4.2% RSD. The consumption of the samples and reagents was ca. 170 µL per analysis cycle.