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Abyssomicin derivatives from the rhizosphere soil actinomycete Microbispora rhizosphaerae sp. nov. TBRC6028
Author(s)
Bunbamrung, Nantiya
Kittisrisopit, Suchada
Intaraudom, Chakapong
Dramae, Aibrohim
Niemhom, Nantawan
Harding, David J.
Auncharoen, Patchanee
Pittayakhajonwut, Pattama
Date Issued
May 1, 2021
Type
Article
Abstract
Three undescribed abyssomicin derivatives, including microbimisin, abyssomicins Z1, and Z2, were isolated from the soil actinomycete Microbispora rhizosphaerae sp. nov. TBRC6028. Chemical structures were determined by NMR spectroscopic data (1H, 13C, COSY, HSQC, HMBC, and NOESY spectra) and the absolute configurations were verified by single-crystal X-ray diffraction analyses together with the ECD spectral data. Microbimisin and abyssomicin Z1 exhibited weak antibacterial activity against Bacillus cereus with MIC values of 25.0 and 50.0 μg/mL without cytotoxicity against MCF-7 and Vero cells at the concentration of 50 μg/mL.
Citation
Phytochemistry, 185, 2021