Classification of in Vitro Blood Stages of Plasmodium Falciparum Based on Fuzzy Inference System

Abstract

This paper proposes the automated texture based classification of Malaria parasites in Giemsa-stained thin blood film images based on fuzzy inference system (FIS). The proposed expert and knowledge based framework includes the segmentation, feature extraction and classification of erythrocytes. First-order statistical analysis includes mean, standard deviation, skewness and kurtosis have been proposed as input parameters of FIS. The effectiveness of classifier is compared to find appropriate parame- ters for classification of normal cells and infected cells, both ring and trophozoite stages. The proposed method can provide 96.28% accuracy rate for binary classification of normal and infected cells. The results also yield 97.55% accuracy for ring stage classification, and 98.54% accuracy for trophozoite stage classification.