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The biological activities of the methanolic extract of santol (Sandoricum koetjape) fruits
Author(s)
Pedklang, N.
Date Issued
March 1, 2024
Type
Article
Abstract
The biological activities of phytochemical, antibacterial, antioxidant, anti-tyrosinase and cytotoxic activities from flesh and peel of santol (Sandoricum koetjape) fruit by macerating with methanol were inverstigated. Phytochemical screening in the methanolic extracts revealed the presence of tannin, coumarin and betacyanin. Saponin was found only in the flesh, and alkaloid was found only in the peel extracts. For antibacterial activity, the extract concentration at 2000 micrograms per disc was found to be inhibitory effects on the growth of Bacillus cereus and Staphylococcus aureus but no inhibitory effect on the growth of Escherichia coli. DPPH and ABTS methods for antioxidant activity, the peel extract exhibited higher activity than the flesh extract. The IC50 values of methanolic extracts from the peel of santol fruit were 30 and 48 micrograms per milliliter for DPPH and ABTS, respectively. Tyrosinase inhibitory activity was determined by the dopa-chrome method. The peel extract showed higher tyrosinase inhibitory activity than the flesh extract, with 76.37% at 1 milligram per milliliter. For cytotoxicity activity, the flesh and peel of santol extracts at a concentration of 2000 micrograms per milliliter showed the cytotoxic effect on the human colorectal adenocarcinoma cell line (HT-29) and African green monkey kidney cell line (Vero) at 47.39 and 37.18 percent, respectively. This research showed the pharmacological potential of the santol fruit extracts for further testing to develop as products.
Citation
International Journal of Agricultural Technology, 20(2), 749-760, 2024