Polymer based microneedle patch fabricated using microinjection moulding

Janphuang, Pattanaphong; Laebua, Mongkhol; Sriphung, Chanwut; Taweewat, Phatsakon; Sirichalarmkul, Anan; Sukjantha, Kasiphisan; Promsawat, Napatporn; Leuasoongnoen, Pimchanok; Suphachiaraphan, Somphong; Phimol, Kantapon; Isarakorn, Don; Tancharakorn, Somchai

doi:10.1051/matecconf/201819201039

Polymer based microneedle patch fabricated using microinjection moulding

Author(s)

Janphuang, Pattanaphong

Laebua, Mongkhol

Sriphung, Chanwut

Taweewat, Phatsakon

Sirichalarmkul, Anan

Sukjantha, Kasiphisan

Promsawat, Napatporn

Leuasoongnoen, Pimchanok

Suphachiaraphan, Somphong

Phimol, Kantapon

Isarakorn, Don

Tancharakorn, Somchai

Date Issued

August 14, 2018

Type

Conference Paper

DOI

10.1051/matecconf/201819201039

Abstract

This paper presents the development of a polymer based microneedle patch for transdermal drug delivery application using plastic microinjection moulding. Design and analysis of the microneedle cavities and mould insert used in the injection moulding process were carried out using Computer-Aided Engineering (CAE) software. A mould insert with low surface roughness was fabricated using Micro Electrical Discharge Machining (μ-EDM). The injection moulding parameters including clamping force, temperature, injection pressure and velocity were characterized in order to obtain the optimum reproducibility. Solid truncated cone microneedles, made of biocompatible polymethyl methacrylate (PMMA), with a round tip radius of 50 μm and 500 μm in height have been realized by microinjection moulding process demonstrating the potential of a low cost, high production efficiency, and suitable for mass production. In addition, a mould insert of cylindrical microneedles fabricated using X-ray LIGA has been proposed.

Citation

Matec Web of Conferences, 192, 2018