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Characterization of an antibacterial wound dressing from basil seed (Ocimum basilicum L.) mucilage-ZnO nanocomposite
Author(s)
Tantiwatcharothai, Siriporn
Date Issued
August 15, 2019
Type
Article
Abstract
The large water holding capacity of Basil Seed (Ocimum basilicum L.) Mucilage (BSM) gives it potential to produce a valuable polymer for water holding applications such as wound dressing. The objective of this research was to prepare a natural-based antibacterial wound dressing from BSM by freeze-drying. Various contents of zinc oxide nanoparticles (ZnO-NP) were incorporated as an antibacterial agent. BSM hydrogel sponge showed considerable porosity and degree of swelling. From FTIR analysis, hydrogen bond and electrostatic interaction between BSM molecules and ZnO-NP were confirmed. SEM images revealed an interconnecting open-cell structure of pores in the BSM hydrogel sponge with a good distribution of ZnO-NP. Moreover, increase in ZnO-NP content improved the mechanical properties (stress at maximum load 8.9 MPa, Young's modulus 151 MPa and strain at maximum load 51%), thermal properties, water retention capacity and antibacterial activity. Cytotoxicity and cell adhesion studies of BSM hydrogel sponge indicated non-cytotoxicity and non-adherent nature of the sponge.
Citation
International Journal of Biological Macromolecules, 135, 133-140, 2019