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Novel Electrochemical Flow Injection Procedure for Albendazole Determination using Boron-doped Diamond thin Film Electrode
Author(s)
Watthanachaiyapong Janhom
Rannurags, Narabhats
Kongsakphaisal, Arunee
Sirisungworwong, Wasan
Liawruangrath, Saisunee
Date Issued
May 1, 2019
Type
Article
Abstract
Abstract: The homemade electrochemical cell for electrochemical determination of albendazole using boron-doped diamond (BDD) thin film electrode is developed. Electrochemical activity of albendazole was investigated by cyclic voltammetry in 0.10 M phosphate buffer containing 20% (v/v) methanol at pH 2.5. Using the BDD electrode well-defined and highly reproducible cyclic voltammogram was obtained with current signal-to-background ratio of higher than those obtained from the glassy carbon electrode. Flow injection analysis system with amperometric detection using the homemade thin-layer electrochemical flow-through cell with BDD electrode was studied. The hydrodynamic voltammogram of the drug exhibited single well defined maximum oxidation peak at 0.95 V versus Ag/AgCl. A low detection limit of 2 ppm was obtained. The current–concentration relationship was rectilinear over the concentration range of 3.3‒150 ppm. The proposed method was applied to albendazole tablets with satisfactory results.
Citation
Journal of Analytical Chemistry, 74(5), 513-519, 2019