Loading...
Diterpene glycosides from Holothuria scabra exert the α-synuclein degradation and neuroprotection against α-synuclein-Mediated neurodegeneration in C. elegans model
Author(s)
Chalorak, Pawanrat
Sornkaew, Nilubon
Manohong, Preeyanuch
Niamnont, Nakorn
Malaiwong, Nawaphat
Sobhon, Prasert
Aschner, Michael
Meemon, Krai
Date Issued
October 28, 2021
Type
Article
Abstract
Ethnopharmacological relevance: Holothuria (Metriatyla) scabra Jaeger (H. scabra), sea cucumber, is the marine organism that has been used as traditional food and medicine to gain the health benefits since ancient time. Although our recent studies have shown that crude extracts from H. scabra exhibited neuroprotective effects against Parkinson's disease (PD), the underlying mechanisms and bioactive compounds are still unknown. Aim of the study: In the present study, we examined the efficacy of purified compounds from H. scabra and their underlying mechanism on α-synuclein degradation and neuroprotection against α-synuclein-mediated neurodegeneration in a transgenic Caenorhabditis elegans PD model. Material and methods: The H. scabra compounds (HSEA-P1 and P2) were purified and examined for their toxicity and optimal dose-range by food-clearance and lifespan assays. The α-synuclein degradation and neuroprotection against α-synuclein-mediated neurodegeneration were determined using transgenic C. elegans model, Punc-54
Citation
Journal of Ethnopharmacology, 279, 2021