Directed-evolution approach to empower EGFR targeting for immunotherapy

Meksiriporn, Bunyarit; Spangler, Jamie B.

doi:10.1016/j.crmeth.2024.100762

Directed-evolution approach to empower EGFR targeting for immunotherapy

Author(s)

Meksiriporn, Bunyarit

Spangler, Jamie B.

Date Issued

April 22, 2024

Type

Note

DOI

10.1016/j.crmeth.2024.100762

Abstract

Advances in directed-evolution technologies are enabling new strategies to isolate binding proteins that recognize disease-associated states of a target protein. In this issue of Cell Reports Methods, Dobersberger et al. devised a yeast display-based selection scheme to discover proteins that engage the cancer-associated activated state of a receptor to enable design of safe and effective immunotherapies.

Citation

Cell Reports Methods, 4(4), 2024