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Antibacterial, antitubercular, antimalarial and cytotoxic substances from the endophytic Streptomyces sp. TBRC7642
Author(s)
Bunbamrung, Nantiya
Intaraudom, Chakapong
Dramae, Aibrohim
Tadtong, Sarin
Auncharoen, Patchanee
Pittayakhajonwut, Pattama
Date Issued
April 1, 2020
Type
Article
Abstract
Eight previously undescribed naturally-occurring compounds, including abyssomycins Y - Z, methyl aeruginoate, desferri-ferrithocin-4-hydroxyphenethylester, streptomethiocins A - B, furaquinocin I, and streptolactone, along with eleven known compounds were isolated from the endophytic Streptomyces sp. TBRC7642. The chemical structures were determined based on spectroscopic means including 1D, 2D NMR spectroscopy and mass spectrometry. The absolute configurations were assigned by relying on CD spectra and their optical rotations. In addition, the isolated compounds were evaluated for biological activity, such as antimalarial, antitubercular, antibacterial (both Gram-positive and Gram-negative bacteria), as well as for cytotoxicity against MCF-7, NCI–H187, and Vero cells.
Citation
Phytochemistry, 172, 2020