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Synthesis of Cyclodextrin-Grafted Chitosan: From Laboratory Scale to Pilot Scale
Author(s)
Phunpee, Sarunya
Ruktanonchai, Uracha Rungsardthong
Surassmo, Suvimol
Methaapanon, Rungthiwa
Vacharanukrauh, Treerat
Assabumrungrat, Suttichai
Soottitantawat, Apinan
Date Issued
December 15, 2023
Type
Article
Abstract
The CD-g-CS complex particle, made from the synthesis of toluenesulfonyl β-cyclodextrin (TsCD) and chitosan (CS), has a wide range of applications. Previous laboratory studies have proven the feasibility of the synthesis process, but larger-scale studies are necessary for wide utilization. This study aimed to scale up the reaction process from a 250 mL laboratory scale to 2, 10, and 500 L batch stirred-tank reactors, using a stepwise approach. Factors such as the mole ratio of TsCD to CS, reaction temperature, and reaction time were studied to optimize the synthesis. The degree of N-substitution (DS) was used to assess the number of grafted TsCD per primary amino group of chitosan, which is the key measure of the high-quality CD-g-CS. The results indicated that the DS increased with the increasing TsCD to CS mole ratio and reached a maximum at a reaction temperature of 95 °C. The reaction reached optimum results after 24 h. The constant heat transfer rate per unit volume was used as a successful scaling factor for the 10 and 500 L CD-g-CS processes.
Citation
Organic Process Research and Development, 27(12), 2309-2316, 2023