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Inclusion complex of water-soluble arbutin with β-cyclodextrin: Computer modeling and experimental studies
Author(s)
Rujipairoj, Supawan
Surassmo, Suvimol
Ruktanonchai, Uracha Rungsardthong
Phunpee, Sarunya
Ali, Saba
Darai, Nitchakan
Rungrotmongkol, Thanyada
Soottitantawat, Apinan
Date Issued
March 1, 2025
Type
Article
Abstract
A water-soluble arbutin was investigated for its potential to form an inclusion complex with β-cyclodextrin (β-CD). Molecular modeling tests confirmed that arbutin can be accommodated within the cavity of β-CD primarily through Van der Waals forces rather than electrostatic interactions. The structure of the arbutin-β-CD inclusion complex was characterized using Differential Scanning Calorimetry (DSC), and Proton Nuclear Magnetic Resonance Spectroscopy (1H NMR). The inclusion complex prepared at a mole ratio of 1:1 (arbutin: β-CD) exhibited the highest encapsulation efficiency at 43.72 %. The study findings affirm that encapsulation of arbutin within β-CD does not reduce its inherent antioxidant activity and its inhibitory effects against tyrosinase enzyme activity. Moreover, the complexation of arbutin with β-CD resulted in a notably slower release rate, indicating the role of β-CD in modulating substance release kinetics. Furthermore, encapsulation of arbutin within β-CD demonstrated a reduction in hydrolysis from arbutin to hydroquinone by Staphylococcus epidermidis, highlighting the potential of the inclusion complex to mitigate enzymatic conversion processes.
Citation
Carbohydrate Polymer Technologies and Applications, 9, 2025