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Subchronic toxicity of liquid smoke from 'Tian Op' in Wistar rats
Author(s)
Watcharananun, Wanwarang
Chivapat, Songpol
Rangsripipat, Anudep
Attawish, Aimmanas
Chavalittumrong, Pranee
Padungpat, Songpol
Hungrak, Kittipong
Date Issued
July 18, 2013
Type
Article
Abstract
Liquid smoke (LS) from 'Tian Op ' has been developed for 'feathering' (softening) the odor of many Thai desserts. The benefits of liquid smoke are reduced smoking time, increased ease of utilization and standardization of the intensity of the flavor in dessert products. The Medicinal Plant Research Institute, Department of Medical Science, Ministry of Public Health, Thailand conducted a 90 d oral subchronic toxicity test of LS in 120 Wistar rats divided into five groups (12 per sex per group). Groups 1 and 2 were control groups receiving distilled water and propylene glycol at a volume of 10 mL.kg-1. day-1, respectively, where the weight was based on live body weight. Groups 3-5 were experimental groups receiving LS at doses of 0.04, 0.4 and 4.0 g.kg-1.day-1, respectively. LS at any dosage did not affect growth, food consumption and hematological values. Rats receiving LS at doses of 0.4 and 4.0 mL.kg-1.day-1 had significantly higher albumin levels than the water control and the propylene glycol-treated rats, but these alterations did not indicate any abnormalities. Histopathology of organs revealed no abnormalities related to liquid smoke toxicity. Therefore, it may be concluded that liquid smoke at the given dosages did not produce toxicity in Wistar rats.
Citation
Kasetsart Journal Natural Science, 47(1), 42-52, 2013
Subjects