Discovery of Streptomyces marinisediminis sp. nov., a new thiolutin producing actinomycete isolated from Thai marine sediment

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dc.contributor.authorRawirat Pansomsuay
dc.contributor.authorPoowadon Fukasem
dc.contributor.authorPattama Pittayakhajonwut
dc.contributor.authorChakapong Intaraudom
dc.contributor.authorChanwit Suriyachadkun
dc.contributor.authorMontri Yasawong
dc.contributor.authorYa‐Wen He
dc.contributor.authorSomboon Tanasupawat
dc.contributor.authorQian Yang
dc.contributor.authorChitti Thawai
dc.date.accessioned2026-05-08T19:17:03Z
dc.date.issued2025-8-11
dc.description.abstractexhibited strong antimicrobial activity against Gram-positive bacteria and led to the discovery of two promising secondary metabolites, thiolutin and 2,2-dioxidothiolutin, along with 8-amino-2H-benz[e][1,3]oxazine-2,4(3H)-dione, benadrostin, 2,3-dihydroxybenzamide, and 2-hydroxy-3-methoxybenzamide. In this study, 2,2-dioxidothiolutin was structurally confirmed for the first time by X-ray crystallographic analysis. Interestingly, thiolutin demonstrated strong anti-human small cell lung cancer (NCI-H187) activity, with an IC₅₀ value of 0.35 µg/mL, and also showed cytotoxicity against human breast cancer (MCF-7) cells, with an IC₅₀ value of 5.61 µg/mL.
dc.identifier.doi10.1038/s41598-025-15081-x
dc.identifier.urihttps://dspace.kmitl.ac.th/handle/123456789/15820
dc.publisherScientific Reports
dc.subjectGenomics and Phylogenetic Studies
dc.subjectMicrobial Natural Products and Biosynthesis
dc.subjectMarine Sponges and Natural Products
dc.titleDiscovery of Streptomyces marinisediminis sp. nov., a new thiolutin producing actinomycete isolated from Thai marine sediment
dc.typeArticle

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