Preparation, biological evaluation and QSAR analysis of urea substituted 2,4-diamino-pyrimidine anti-malarials
| dc.contributor.author | Borvornwat Toviwek | |
| dc.contributor.author | Jennifer Riley | |
| dc.contributor.author | Nicole Mutter | |
| dc.contributor.author | Mark Anderson | |
| dc.contributor.author | Lauren Webster | |
| dc.contributor.author | Irene Hallyburton | |
| dc.contributor.author | Duangkamol Gleeson | |
| dc.contributor.author | Kevin D. Read | |
| dc.contributor.author | M. Paul Gleeson | |
| dc.date.accessioned | 2026-05-08T19:17:57Z | |
| dc.date.issued | 2022-1-1 | |
| dc.description.abstract | 3D7 (0.09 μM), good selectivity with respect to mammalian cytotoxicity (SI = 54) and low microsomal clearance. Quantitative structure activity relationship (QSAR) analyses point to lipophilicity being a key driver of improved anti-malarial activity. The most active compounds in the series suffered from high lipophilicity, poor aqueous solubility and low permeability. The results provide useful information to guide further chemistry iterations. | |
| dc.identifier.doi | 10.1039/d2md00218c | |
| dc.identifier.uri | https://dspace.kmitl.ac.th/handle/123456789/16295 | |
| dc.publisher | RSC Medicinal Chemistry | |
| dc.subject | Synthesis and biological activity | |
| dc.subject | HIV/AIDS drug development and treatment | |
| dc.subject | Computational Drug Discovery Methods | |
| dc.title | Preparation, biological evaluation and QSAR analysis of urea substituted 2,4-diamino-pyrimidine anti-malarials | |
| dc.type | Article |