Electrochemical Characterization of a Molecularly Imprinted Polymer Sensor for the Selective Recognition of Type II Collagen in Joint Degeneration Monitoring

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dc.contributor.authorNampeng, Jindapa
dc.contributor.authorVongmanee, Naphatsawan
dc.contributor.authorPintavirooj, Chuchart
dc.contributor.authorVisitsattapongse, Sarinporn
dc.date.accessioned2026-08-06T10:54:33Z
dc.date.available2026-08-06T10:54:33Z
dc.date.issued2026-02-01
dc.description.abstractType II collagen is a primary fibrillar component of articular cartilage, and its early degradation is a key biomarker of joint-degenerative disorders such as osteoarthritis, rheumatoid arthritis, gout, etc. Reliable detection at low concentrations remains challenging due to limited assay accessibility, complex analytical procedures, and nonspecific responses in multicomponent biological matrices. This research reports the development of a Molecularly Imprinted Polymer (MIP)–based electrochemical sensor engineered for the selective recognition of type II collagen. A series of monomer formulations were evaluated, and the 1AAM:2VP composition produced a well-defined imprinted layer on screen-printed carbon electrodes, yielding the highest electrochemical sensitivity and linearity. The optimized sensor exhibited strong anodic and cathodic responses proportional to increasing collagen concentrations, with a calibration slope corresponding to an R<sup>2</sup> value of 0.9394. Minimal signal interference was observed, confirming high molecular selectivity. The limit of detection (LOD) was calculated to be approximately 0.065 µg/mL. These characteristics demonstrate that the proposed MIP sensor provides a low-cost, accessible, and highly selective analytical platform suitable for early-stage cartilage degeneration monitoring.
dc.identifier.citationPolymers, 18(3), 2026
dc.identifier.doi10.3390/polym18030321
dc.identifier.issn20734360
dc.identifier.other2-s2.0-105030926957
dc.identifier.urihttps://dspace.kmitl.ac.th/handle/123456789/17861
dc.sourcePolymers
dc.subjectarthritis biomarkers
dc.subjectcartilage degradation
dc.subjectcollagen type II
dc.subjectelectrochemical biosensor
dc.subjectjoint degeneration monitoring
dc.subjectmolecularly imprinted polymer
dc.subjectpolymerization
dc.subjectscreen-printed electrode
dc.titleElectrochemical Characterization of a Molecularly Imprinted Polymer Sensor for the Selective Recognition of Type II Collagen in Joint Degeneration Monitoring
dc.typeArticle

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