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Author: search.filters.author.Khemasiri, NarathonSubject: search.filters.subject.Laser-induced graphene

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    Laser-induced graphene electrochemical immunosensors for rapid and sensitive serological detection: A case study on dengue detection platform
    (2025-06-01)
    Inlumphan, Supawee
    ;
    Wongwiriyapan, Winadda
    ;
    Khemasiri, Narathon
    ;
    Rattanawarinchai, Prapakorn
    ;
    Leepheng, Piyawan
    Here, we present a diagnostic on a chip platform based on laser-induced graphene (LIG) electrochemical immunosensors for serological detection. The electrochemical immunosensors are fabricated through CO<inf>2</inf> laser induction on polyimide (PI) sheets. Optimal electrochemical activity of LIG electrodes is obtained under optimized conditions of laser fluence. To verify the application, the serological detection platform was demonstrated. After functionalization with dengue virus (DENV) antigen, the LIG electrochemical immunosensors are able to sense the presence of mouse anti-flavivirus monoclonal (4G2) antibody in a wide linear working range of 25–20,000 ng/ml with the limit of detection (LOD) of 17.41 ng/ml. A specific recognition with 4G2 antibodies against with media protein and isotype is confirmed. Furthermore, the reliability of LIG electrochemical immunosensors compared to conventional enzyme-linked immunosorbent assay (ELISA) is verified through the NS1 antibodies identification in human blood serum clinical samples at room temperature. Our results highlight that the LIG-based electrode is a promising platform for electrochemical immunosensors, aimed at developing reliable and practical diagnostic tools for serological detection. These tools enable early diagnosis of infectious diseases, as well as non-invasive and rapid screening.
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    Low resistance bisphenol-A based polybenzoxazine derived laser-induced graphene (LIG) and its microsupercapacitor application
    (2024-11-01)
    Luengrojanakul, Panuwat
    ;
    Klamchuen, Annop
    ;
    Khemasiri, Narathon
    ;
    Chotsuwan, Chuleekorn
    ;
    Charoensuk, Krittapas
    Herein, we demonstrate the use of conventional BA-a based polybenzoxazine as a laser-induced graphene (LIG) forming precursor. The effects of laser power and the engraving speed on formation and properties of LIG are explored. By optimizing the laser fluency related to laser power along with engraving speed, poly(BA-a) derived LIG with high graphitization degree and low sheet resistance (R<inf>s</inf>) of ∼ 2–10 Ω/sq can be acquired. The morphologies and surface area of LIGs in such low R<inf>s</inf> region are then validated through SEM and BET, respectively. The resulting poly(BA-a) derived LIG exhibits a high amount of macropores in the structure with marginal differences in the specific surface area being 27–88 m<sup>2</sup>/g. In addition, electrochemical performances of the two-electrode based microsupercapacitor (LIG-MSC) of the selected samples in low R<inf>s</inf> region with different specific surface area are evaluated. The LIG-MSC shows a specific capacitance of 1.39 mF/cm<sup>2</sup> (0.04 mA/cm<sup>2</sup>), and good cycling stability of 10,000 cycles with capacitance retention of 92% (0.2 mA/cm<sup>2</sup>). Our results highlight that poly(BA-a) derived LIG is promising for high performance LIG applications.