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Author: search.filters.author.Tantiwatcharothai, SiripornSubject: search.filters.subject.ZnO nanoparticles

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    Property improvement of antibacterial wound dressing from basil seed (O. basilicum L.) mucilage- ZnO nanocomposite by borax crosslinking
    (2020-01-01)
    Tantiwatcharothai, Siriporn
    ;
    Prachayawarakorn, Jutarat
    Some applications, in particular, wound dressings, require significant water holding capability: hydrogels formed from Basil seed mucilage (BSM) are non-toxic natural substances and exhibit the needed water holding capacity. However, the sponges have low dimensional stability and easily degrade in aqueous media. We overcame this drawback by crosslinking with borax. To provide antibacterial activity, zinc oxide nanoparticles (ZnO-NP) were added. With 10–20 wt% added borax and ZnO-NP, all key properties improved: dimensional stability, water retention capacity (31 to 41%), stress at maximum load (2.6 to 6.6 MPa), Young's modulus (74 to 113 MPa) and strain (28 to 54%). An interconnecting system of pores with well distributed ZnO-NP was observed from scanning electron microscope. In addition, higher borax and ZnO-NP loadings slightly decreased porosity (92% to 73%) and swelling (109 to 56). Moreover, antibacterial activity and cytotoxicity of BSM hydrogel sponge were also examined.
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    Characterization of an antibacterial wound dressing from basil seed (Ocimum basilicum L.) mucilage-ZnO nanocomposite
    (2019-08-15)
    Tantiwatcharothai, Siriporn
    ;
    Prachayawarakorn, Jutarat
    The large water holding capacity of Basil Seed (Ocimum basilicum L.) Mucilage (BSM) gives it potential to produce a valuable polymer for water holding applications such as wound dressing. The objective of this research was to prepare a natural-based antibacterial wound dressing from BSM by freeze-drying. Various contents of zinc oxide nanoparticles (ZnO-NP) were incorporated as an antibacterial agent. BSM hydrogel sponge showed considerable porosity and degree of swelling. From FTIR analysis, hydrogen bond and electrostatic interaction between BSM molecules and ZnO-NP were confirmed. SEM images revealed an interconnecting open-cell structure of pores in the BSM hydrogel sponge with a good distribution of ZnO-NP. Moreover, increase in ZnO-NP content improved the mechanical properties (stress at maximum load 8.9 MPa, Young's modulus 151 MPa and strain at maximum load 51%), thermal properties, water retention capacity and antibacterial activity. Cytotoxicity and cell adhesion studies of BSM hydrogel sponge indicated non-cytotoxicity and non-adherent nature of the sponge.