Boonyarattanakalin, Kanokthip
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Boonyarattanakalin, Kanokthip
Alternative Name
BOONYARATTANAKALIN, Kanokthip
Boonyarattanakalin, K.
Main Affiliation
Email
kanokthip.bo@kmitl.ac.th
21 results
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Item type:Publication, A novel potent autophagy inhibitor ECDD-S27 targets vacuolar ATPase and inhibits cancer cell survival(2019-12-01) ;Paha, Jiraporn ;Kanjanasirirat, Phongthon ;Munyoo, Bamroong ;Tuchinda, PatoomratanaSuvannang, NaravutAutophagy is a conserved lysosomal-dependent cellular degradation process and its dysregulation has been linked to numerous diseases including neurodegeneration, infectious diseases, and cancer. Modulation of autophagy is therefore considered as an attractive target for disease intervention. We carried out a high-content image analysis screen of natural product-derived compounds to discover novel autophagy modulating molecules. Our screen identified ECDD-S27 as the most effective compound for increasing the number of autophagic vacuoles inside cells. The structure of ECDD-S27 revealed that it is a derivative of cleistanthin A, a natural arylnaphthalene lignan glycoside found in plants. ECDD-S27 increases the number of autophagic vacuoles by inhibiting the autophagic flux and is able to restrict the survival of different cancer cells at low nanomolar concentrations. Molecular docking and SERS analysis showed that ECDD-S27 may potentially target the V-ATPase. Upon treatment of various cancer cells with ECDD-S27, the V-ATPase activity is potently inhibited thereby resulting in the loss of lysosomal acidification. Taken together, these data indicated that ECDD-S27 retards the autophagy pathway by targeting the V-ATPase and inhibits cancer cell survival. The observed antitumor activity without cytotoxicity to normal cells suggests the therapeutic potential warranting further studies on lead optimization of the compound for cancer treatment. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Characterization and x-ray absorption spectroscopy of ilmenite nanoparticles derived from natural ilmenite ore via acidassisted mechanical ball-milling process(2017-09-01) ;Phoohinkong, Weerachon ;Pavasupree, Sorapong ;Wannagon, Anucha ;Sanguanpak, SamunyaIn this work activated ilmenite nanoparticles were prepared by chemical-assisted in mechanical ball-milling process from ilmenite ore as starting raw material. The effect of milling process on their phase composition, particle size, surface morphology and local structure were investigated. Phase identification and crystalline structure of ilmenite mineral, milled samples and subsequent leached residues were characterized by x-ray diffraction (XRD). Meanwhile, the distorted octahedral structure and the oxidation state of relevant elements in ilmenite ore and activated ilmenite obtained by different process conditions were analyzed by x-ray absorption spectroscopy (XAS). Particle size and morphologies of the samples were monitored by field emission scanning electron microscope (FESEM) and transmission electron microscope (TEM). Three dominant peaks of TiO2 rutile, FeTiO<inf>3</inf>, and Fe<inf>2</inf>TiO<inf>4</inf> are obviously adulterated in XRD patterns after mechanical milling with water and acid solution when comparing to precursor mineral. However, the contaminated phase of FeTiO3 and Fe<inf>2</inf>TiO<inf>4</inf> was readily decreased by acid-assisted mechanical ball-milling. The enhancement in leaching process of ilmenite residue after milling can be obtained with sulfuric acid. This result suggests that iron contaminated phase could be leached from the sample resulting to the decrease in Fe environment around Ti atom. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Adsorbed protein on P25 nanoparticles-synthesis, characterization and electrochemical property(2018-09-05) ;Phoohinkong, Weerachon ;Sukonket, ThitinartKeratin modification on surface of titanium dioxide P25 was carried out from titanium dioxide suspension and keratin solution extracted from swine wool. The existence of amide component, protein functional groups dissociated to active protein moieties and attached to titanium dioxide surface in form of hybrid nanomaterial were characterized by Fourier-transform infrared spectroscopy (FT-IR). The keratin protein decorated on particle surfaces was observed by Field Emission Scanning Electron Microscopy (FESEM). Chemical states and bonding at the nano-biomolecule interfaces with titanium dioxide were investigated using X-ray Photoelectron Spectroscopy (XPS). Protein concentration is considered as roles for protein modification, surface bonding, chemical states and protein adsorption. The Ti<sup>3+</sup> and Ti<sup>2+</sup> surface and high adsorption degree can be obtained at low concentration of protein solution with P25. However, the strong bonding between protein and TiO<inf>2</inf> obtained in high protein concentration with Ti<sup>3+</sup> and Ti<sup>2+</sup> species result disappear for Ti<sup>3+</sup> and Ti<sup>2+</sup> XPS peaks. The adsorbed protein reveals secondary structure of random coil keratin with strong bonding conjugated to the titanium dioxide surface. The strong binding between protein and TiO<inf>2</inf> surface in this novel protein-TiO<inf>2</inf> hybrid material shows a promising alternative way for advance tunable electronic structure and charge transport mechanism which enhance electrochemical capacitance by mean of double layer and pseudo-capacitive behavior. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Effects of seeding layer thickness on physical and morphological structure of Ga/F co-doped ZnO nanostructures(2017-01-01) ;Chongsri, Krisana; The effects of seed layer thickness on structural properties and morphology of Ga/F co-doped ZnO nanostructures were investigated in this work. The seed layers with various thicknesses were deposited on glass substrates by dip-coating. It is hypothesized that a certain range of seed layer thickness can significantly alter the outcomes of the morphological structure, density, and shape of the as-synthesized nanostructure products. The Ga/F co-doped ZnO nanostructures were grown on these seed layers by a hydrothermal process using Zn(NO<inf>3</inf>)<inf>2</inf>, NH<inf>4</inf>F, GaN<inf>3</inf>O<inf>9</inf> and hexamethyltetramine. The effects of seeding layer thickness on morphologies and structural properties were investigated by X-ray diffraction (XRD), scanning electron microscope (SEM), and UV-Vis spectroscopy. More detailed studies to clarify the seed layer effect on the growth of Ga/F co-doped ZnO nanostructures are further discussed. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Investigation on influence of seeding layer on morphological properties of ZnO-based nanostructure prepared by hydrothermal process(2018-01-01) ;Chongsri, Krisana; In this present work, bare ZnO low-dimensional structures were synthesized by hydrothermal process with crystal growth assistance using seed layers. Different seeding layer species including ZnO and Ga-doped ZnO films prepared by sol-gel dip coating were introduced onto the substrate before the hydrothermal growth of ZnO-based nanostructures. Zn(NO<inf>3</inf>)<inf>2</inf> and GaN<inf>3</inf>O<inf>9</inf> were utilized as Zn and Ga source during hydrothermal process. The influence of seeding layer types on morphological and shapes of the hydrothermally grown nanostructures have been extensively scrutinized by Field emission scanning electron microscope (FE-SEM), X-ray diffraction (XRD) and optical spectroscopy. It was revealed that different morphologies and exceptional shapes in form of nanorods of ZnO-based nanostructures were obtained as different seeding layers were introduced. More detailed studies for clarification of seed layer effect on the growth of ZnO-based nanostructures are mentioned and discussed. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Effect of F incorporation on physical and optical properties of hydrothermally grown ZnO nanorods(2018-01-01) ;Sinornate, Wuttichai ;Chongsri, Krisana; F-doped ZnO nanorods were synthesized via hydrothermal process with variation of Fluorine doping contents (0-10%) starting from zinc oxide thin film as a seeding layer for nanorod growth. The zinc oxide seeding thin film was prepared by sol-gel spin coating at 2000 rpm on glass substrate using zinc acetate precursor with annealing at 500°C in air for 2 h. Ammonium fluoride (NH<inf>4</inf>F) was used as F doping precursor. The properties of F-doped ZnO nanorods were characterized by field emission electron microscope (FESEM), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX) and UV-Visible spectrophotometer. Corresponding results indicated that growth of ZnO:F nanorods with good crystallinity and grown in (002) plane in undoped ZnO and F-doped ZnO 5%. The average size diameter of undoped and F-doped ZnO nanorods at 3%, 5% and 10% are 56, 96, 70 and 103 nm, respectively. From cross section images the average length of undoped and F-doped ZnO nanorods at 3%, 5% and 10% are 400, 375, 199 and 478 nm, respectively. The transmittance spectra shows moderate transparency (<80%) of the ZnO nanorod film in visible region with corresponding band gap range of 3.25-3.28 eV. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Extraction and characterization of nanocellulose from sugarcane bagasse by ball-milling-assisted acid hydrolysis(2018-09-05) ;Plermjai, Kittiya; ; ;Pavasupree, SorapongPhoohinkong, WeerachonThis study is proposed to characterize nanocellulose extracted from sugarcane bagasse (SCB). For extracting cellulose, the bagasse was treated by chemical treatment. The nanocellulose was prepared using ball-milling with acid hydrolysis. Morphology of bagasse, cellulose and nanocellulose were characterized by scanning electron microscopy (SEM). The chemical composition of extracted cellulose and nanocellulose was investigated by Fourier-transformed infrared spectroscopy that verifying the removal of lignin and hemicellulose during cellulose isolation process from sugarcane bagasse. The crystalline structure of cellulose and nanocellulose were characterized by X-ray diffraction (XRD), indicating that the nanocellulose prepared by ball milling with acid hydrolysis has higher crystallinity than nanocellulose prepared only ball milling. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Theoretical Investigation of the Enantioselective [4 + 2] Cycloaddition Reaction of o-Hydroxystyrene and Azlactone(2019-04-05) ;Jensupakarn, Napassorn ;Gleeson, M. Paul; Theoretical studies have been undertaken to rationalize the origin of the enantioselective Diels-Alder reaction (DA) of o-hydroxystyrene and azlactone catalyzed by (a) chiral BINOL-phosphoric acid (CPA) and (b) CPA and chiral guanidine (TBO). The sequence of events leading to increased enantioselectivity under the latter conditions have been studied using density functional theory (DFT) methods. The computational results indicate that both the mono- and co-catalytic processes proceed via stepwise [4 + 2] cycloaddition reactions involving three steps, which are (1) C-C bond formation, (2) C-O bond formation, and (3) the opening of the azlactone ring. This results in the formation of an oxygenous cycle with one chiral center. The origin of greater enantioselectivity under the latter catalytic conditions are discussed in terms of the structural characteristics and energetics of the intermediates and transition states formed on the potential energy surface of the competing reactions. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Optical absorption and FTIR study of cellulose/tio2hybrid composites(2019-05-01) ;Plermjai, Kittiya; ; ;Phoohinkong, WeerachonPavasupree, SorapongCellulose/TiO<inf>2</inf> composite was prepared by conventional mixing using distilled water as medium. The structure and relevant properties of cellulose/TiO<inf>2</inf> composite were characterized by X-ray diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) and UV- Vis spectroscopy. XRD results exhibit typical cellulose structure type I. The absorbance spectra of TiO<inf>2</inf>and cellulose exist in vicinity of 200 nm and 350 nm in the UV range, corresponding to the UV-C, UV-B and UV-A. In addition, the UV absorption band of the composite can be extended covering wide UV region. Corresponding FTIR results suggest the existence of chemical bonding or surface interaction between TiO<inf>2</inf> and cellulose. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, EFFECT of SEEDING FILM TYPE ON MORPHOLOGY and ELECTRICAL PROPERTIES of Ga-DOPED ZnO NANOSTRUCTURES GROWN by HYDROTHERMAL PROCESS(2018-12-01) ;Chongsri, Krisana; In the present work, we are interested in modifying the structures and electrical properties of Ga-doped ZnO (GZO) nanostructures by incorporation of Ga and F elements into ZnO seeding films. The ZnO, Ga-doped ZnO and F-doped ZnO thin film layers were grown by sol-gel dip coating onto glass substrates. The GZO nanostructures were grown by hydrothermal method starting from zinc nitrate and gallium (III) nitrate hydrate with a crystal growth assistance using the different types of seeding film layers. The X-ray diffractometer (XRD) and field emission scanning electron microscope (FE-SEM) are observe for the crystal structures and surface morphologies of GZO nanostructures. The changes in electrical resistance of the GZO nanostructures due to the different seeding layers were analyzed by the four-point probe technique. It is shown that the structural and electrical properties are found to be affected by the types of seeding layers.
