Paiboon, Narin

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Superparamagnetic nanoparticles encapsulation via droplet-based microfluidics for targeted drug delivery system
(2019-01-01)
Rahong, Sakon
;
Sukthai, Ratchanont
;
Paiboon, Narin
;
Suktham, Kunat
;
Klamchuen, Annop
Here, we present monodispersed superparamagnetic iron oxide nanoparticles (SPIONs)-loaded poly(lactic-coglycolic acid) (PLGA) microdroplets encapsulation by a microfluidic flow-focusing device. SPIONs in PVA solution were employed as a continuous phase and the mixture of PLGA in dichloromethane (DCM) was employed as a disperse phase in the droplet-based microfluidic system. The diameter of microdroplet was carefully controlled and optimize by flow ratio between the dispersed phase and the continuous phase in the microfluidic system. The formation of monodispersed SPIONs-loaded PLGA microdroplet is a matrix particle structure. The magnetization property of microdroplets was characterized and the external magnetic field induced microdroplet also was performed.
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Inclusion complex of water-soluble arbutin with β-cyclodextrin: Computer modeling and experimental studies
(2025-03-01)
Paiboon, Narin
;
Rujipairoj, Supawan
;
Surassmo, Suvimol
;
Ruktanonchai, Uracha Rungsardthong
;
Phunpee, Sarunya
A water-soluble arbutin was investigated for its potential to form an inclusion complex with β-cyclodextrin (β-CD). Molecular modeling tests confirmed that arbutin can be accommodated within the cavity of β-CD primarily through Van der Waals forces rather than electrostatic interactions. The structure of the arbutin-β-CD inclusion complex was characterized using Differential Scanning Calorimetry (DSC), and Proton Nuclear Magnetic Resonance Spectroscopy (<sup>1</sup>H NMR). The inclusion complex prepared at a mole ratio of 1:1 (arbutin: β-CD) exhibited the highest encapsulation efficiency at 43.72 %. The study findings affirm that encapsulation of arbutin within β-CD does not reduce its inherent antioxidant activity and its inhibitory effects against tyrosinase enzyme activity. Moreover, the complexation of arbutin with β-CD resulted in a notably slower release rate, indicating the role of β-CD in modulating substance release kinetics. Furthermore, encapsulation of arbutin within β-CD demonstrated a reduction in hydrolysis from arbutin to hydroquinone by Staphylococcus epidermidis, highlighting the potential of the inclusion complex to mitigate enzymatic conversion processes.
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Synthesis of Cyclodextrin-Grafted Chitosan: From Laboratory Scale to Pilot Scale
(2023-12-15)
Paiboon, Narin
;
Phunpee, Sarunya
;
Ruktanonchai, Uracha Rungsardthong
;
Surassmo, Suvimol
;
Methaapanon, Rungthiwa
The CD-g-CS complex particle, made from the synthesis of toluenesulfonyl β-cyclodextrin (TsCD) and chitosan (CS), has a wide range of applications. Previous laboratory studies have proven the feasibility of the synthesis process, but larger-scale studies are necessary for wide utilization. This study aimed to scale up the reaction process from a 250 mL laboratory scale to 2, 10, and 500 L batch stirred-tank reactors, using a stepwise approach. Factors such as the mole ratio of TsCD to CS, reaction temperature, and reaction time were studied to optimize the synthesis. The degree of N-substitution (DS) was used to assess the number of grafted TsCD per primary amino group of chitosan, which is the key measure of the high-quality CD-g-CS. The results indicated that the DS increased with the increasing TsCD to CS mole ratio and reached a maximum at a reaction temperature of 95 °C. The reaction reached optimum results after 24 h. The constant heat transfer rate per unit volume was used as a successful scaling factor for the 10 and 500 L CD-g-CS processes.

Paiboon, Narin

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