Soytong, Kasem

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Soytong, Kasem
Alternative Name
Soytong, K.
Email
kasem.so@kmitl.ac.th

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    Item type:Publication,
    Chaetomium siamense sp. nov., a soil isolate from Thailand, produces a new chaetoviridin, G
    (2011-01-01)
    Pornsuriya, Chaninun
    ;
    Soytong, Kasem
    ;
    Poeaim, Supattar
    ;
    Kanokmedhakul, Somdej
    ;
    Khumkomkhet, Primmala
    Chaetomium siamense sp. nov., isolated from soil in a pineapple plantation in Thailand, is described and illustrated. The new species is similar to C. cupreum in having superficial globose or ovate ascomata with red circinate ascomatal hairs but can be distinguished by its fusiform ascospores with two apical germ pores. Phylogenetic analysis of ITS rDNA sequence data also supports C. siamense as distinct. Investigation of the secondary metabolites of C. siamense led to the isolation of one new (chaetoviridin G) and seven known compounds (ergosterol, 24(R)-5á,8á-epidioxyergosta-6-22-diene- 3â-ol, ergosterylplamitate, cochliodone D, chaetoviridin A, chaetoviridin F, chrysophanol). © 2011. Mycotaxon, Ltd.
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    Antimalarial and cytotoxic depsidones from the fungus Chaetomium brasiliense
    (2009-08-28)
    Khumkomkhet, Primmala
    ;
    Kanokmedhakul, Somdej
    ;
    Kanokmedhakul, Kwanjai
    ;
    Hahnvajanawong, Chariya
    ;
    Soytong, Kasem
    Four new depsidones, mollicellins K-N (1-4), and six known depsidones, mollicellins B (5), C (6), E (7), F (8), H (9), and J (10), along with two known sterols were isolated from the fungus Chaetomium brasiliense. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic data and chemical transformation. Among these isolates, 1-3, 5-7, and 10 exhibited antimalarial activity against Plasmodium falciparum. Only 1 exhibited antimycobacterial activity against Mycobacterium tuberculosis and antifungal activity against Candida albicans using in vitro assays. In addition, 1-10 showed cytotoxicity against the KB, BC1, NCI-H187, and five cholangiocarcinoma cell lines. © 2009 American Chemical Society and American Society of Pharmacognosy.