Loading...
MYCO-MEDIATED SYNTHESIS AND α-GLUCOSIDASE INHIBITORY ACTIVITY OF SILVER NANOPARTICLES PRODUCED BY XYLARIACEOUS FUNGI
Author(s)
Date Issued
January 1, 2023
Type
Article
Abstract
Metal nanomaterials could be applied in various fields and could be synthesized via living organisms such as plants, bacteria and fungi. Here, the ability of Xylaria sp.5 to produce silver nanoparticles (AgNPs) and α-glucosidase inhibitory activities by the AgNPs produced by Xylaria sp.5 were investigated. The culture broth of Xylaria sp.5 was used to synthesize AgNPs by using 0.1 M of silver nitrate (AgNO3) solutions. The mycogenic crystals were investigated for the morphological characteristics and chemical composition by scanning electron microscope (SEM) equipped with energy dispersive X-ray spectroscopy (EDS), Fourier-transform infrared spectroscopy (FTIR) and X-ray powder diffraction (XRD). The results showed that AgNPs were successfully produced. Moreover, AgNPs were tested for α-glucosidase inhibitory activities. The crude enzyme derived from rat intestine consisted of maltase and sucrase. The percentage of inhibition at 50 mg/ml of maltase and sucrase was 63.21 ± 0.67 and 54.42 ± 0.11, respectively. This study demonstrated that the supernatant culture broth of Xylaria sp.5 can be used to synthesize AgNPs which possess α-glucosidase inhibitory activities. Collectively, this method could be a promising alternative for low cost and non-polluting production of AgNPs which could be potentially utilized for the treatment of type 2 diabetes mellitus.
Citation
Applied Ecology and Environmental Research, 21(5), 4069-4079, 2023