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A new lumazine peptide penilumamide e from the fungus Aspergillus terreus
Author(s)
Chaiyosang, Boonyanoot
Kanokmedhakul, Kwanjai
Boonmak, Jaursup
Youngme, Sujittra
Kukongviriyapan, Veerapol
Kanokmedhakul, Somdej
Date Issued
May 2, 2016
Type
Article
Abstract
A new rare lumazine peptide, penilumamide E (1), together with 13 known compounds (2-14) were isolated from the fungus Aspergillus terreus. Their structures were identified by spectroscopic techniques. The relative configuration of 1 was confirmed by single-crystal X-ray diffraction analysis. Compound 10 exhibited antimalarial activity against Plasmodium falciparum with IC50 values of 2.83 g/mL. Compounds 4 and 6 showed weak cytotoxicity against cholangiocarcinoma (CCA) cell lines. In addition, 4 and 11 exhibited weak cytotoxicity against human hepatoma cell line.
Citation
Natural Product Research, 30(9), 1017-1024, 2016