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Bioactive meroterpenoids and alkaloids from the fungus Eurotium chevalieri
Author(s)
Kanokmedhakul, Kwanjai
Kanokmedhakul, Somdej
Suwannatrai, Ruchiruttikorn
Prabpai, Samran
Kongsaeree, Palangpon
Date Issued
July 29, 2011
Type
Article
Abstract
Five new meroterpenoids, chevalones A-D (1-4), aszonapyrone B (8), and a new sequiterpene alkaloid, eurochevalierine (5), together with four known compounds, sequiterpene (6), terpenoid pyrrolobenzoxazine named CJ-12662 (7), meroterpenoid, aszonapyrone A (9), and ergosterol were isolated from the fungus Eurotium chevalieri. The structures were established on the basis of spectroscopic evidence. The configurations of 1 and 5 were determined by X-ray analysis. The biosynthetic pathway of 1-3, 8, and 9 were proposed. Chemical transformation of aszonapyrone A (9) was also studied. Compounds 4, 5, and 7 exhibited antimalarial activity against Plasmodium falciparum, while 3, 5, and 7 showed antimycobacterial activity against Mycobacterium tuberculosis. In addition, compounds 2-7 showed cytotoxicity against cancer cell lines. © 2011 Elsevier Ltd. All rights reserved.
Citation
Tetrahedron, 67(30), 5461-5468, 2011