Triterpene lactones from cultures of Ganoderma sp. KM01

Lakornwong, Waranya; Kanokmedhakul, Kwanjai; Kanokmedhakul, Somdej; Kongsaeree, Palangpon; Prabpai, Samran; Sibounnavong, Phoutthasone; Soytong, Kasem

doi:10.1021/np400846k

Triterpene lactones from cultures of Ganoderma sp. KM01

Author(s)

Lakornwong, Waranya

Kanokmedhakul, Kwanjai

Kanokmedhakul, Somdej

Kongsaeree, Palangpon

Prabpai, Samran

Sibounnavong, Phoutthasone

Soytong, Kasem

Date Issued

July 25, 2014

Type

Article

DOI

10.1021/np400846k

Abstract

A revised structure of colossolactone G (1), seven new triterpene lactones, ganodermalactones A-G (2-8), and five known triterpene lactones, colossolactone I (9), schisanlactone B (10), colossolactone B (11), colossolactone E (12), and colossolactone IV (13), and ergosterol have been isolated from cultured biomass of the macrofungi Ganoderma sp. KM01. Their structures were identified by spectroscopic methods. Structures and relative configurations of 3, 7, and 8 were confirmed by X-ray crystallographic analysis. Compounds 7, 10, and 12 exhibited antimalarial activity against Plasmodium falciparum in the range 6.0-10.0 μM (IC50). © 2014 The American Chemical Society and American Society of Pharmacognosy.

Citation

Journal of Natural Products, 77(7), 1545-1553, 2014