Antimycobacterial anthraquinone-chromanone compound and diketopiperazine alkaloid from the fungus Chaetomium globosum KMITL-N0802

Kanokmedhakul, Somdej; Kanokmedhakul, Kwanjai; Phonkerd, Nutchanat; Soytong, Kasem; Kongsaeree, Palangpon; Suksamrarn, Apichart

doi:10.1055/s-2002-34415

Antimycobacterial anthraquinone-chromanone compound and diketopiperazine alkaloid from the fungus Chaetomium globosum KMITL-N0802

Author(s)

Kanokmedhakul, Somdej

Kanokmedhakul, Kwanjai

Phonkerd, Nutchanat

Soytong, Kasem

Kongsaeree, Palangpon

Suksamrarn, Apichart

Date Issued

September 1, 2002

Type

Article

DOI

10.1055/s-2002-34415

Abstract

Investigation of the fungus Chaetomium globosum KMITL-N0802 led to the isolation of a novel anthraquinone-chromanone compound named chaetomanone along with seven known compounds, ergosterol, ergosteryl palmitate, chrysophanol, chaetoglobosin C, alternariol monomethyl ether, echinuline and isochaetoglobosin D. These compounds were characterized by spectroscopic methods. Chaetomanone and echinulin exhibited activity towards Mycobacterium tuberculosis.

Citation

Planta Medica, 68(9), 834-836, 2002