Paiboon, Narin

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Superparamagnetic nanoparticles encapsulation via droplet-based microfluidics for targeted drug delivery system
(2019-01-01)
Rahong, Sakon
;
Sukthai, Ratchanont
;
Paiboon, Narin
;
Suktham, Kunat
;
Klamchuen, Annop
Here, we present monodispersed superparamagnetic iron oxide nanoparticles (SPIONs)-loaded poly(lactic-coglycolic acid) (PLGA) microdroplets encapsulation by a microfluidic flow-focusing device. SPIONs in PVA solution were employed as a continuous phase and the mixture of PLGA in dichloromethane (DCM) was employed as a disperse phase in the droplet-based microfluidic system. The diameter of microdroplet was carefully controlled and optimize by flow ratio between the dispersed phase and the continuous phase in the microfluidic system. The formation of monodispersed SPIONs-loaded PLGA microdroplet is a matrix particle structure. The magnetization property of microdroplets was characterized and the external magnetic field induced microdroplet also was performed.
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Microencapsulation of lemongrass oil by spray drying: Role of emulsion size, oil loading, and inlet air temperature on flavor retention and release kinetics
(2026-03-01)
Paiboon, Narin
;
Kaewpanha, Malinee
;
Ruktanonchai, Uracha Rungsardthong
;
Yoshii, Hidefumi
;
Soottitantawat, Apinan
Microencapsulation of lemongrass oil using modified starch (Capsul®) was investigated via spray drying to interpret the process–structure–transport relationships governing flavor retention and release. The effects of oil loading, emulsion size, and inlet air temperature on emulsion characteristics, citral retention, powder morphology, and stability were evaluated. Increasing oil content resulted in larger emulsion droplets, reduced emulsification efficiency, and greater surface oil content, leading to lower citral retention. Capsul® demonstrated high encapsulation performance, retaining up to 40 wt% lemongrass oil with minimal losses. Emulsion droplet size emerged as a key structural determinant, with smaller droplets yielding superior retention and reduced surface oil. By integrating microstructural analysis with kinetic modeling, this study demonstrates that drying-induced particle architecture, rather than retention efficiency alone, governs long-term stability. Release profiles were well described by Avrami kinetics, confirming diffusion-controlled transport, with larger droplets and higher oil loading exhibiting increased effective diffusivity. Although inlet air temperature had minimal influence on immediate citral retention, it strongly affected powder microstructure: higher temperatures produced larger particles with thinner walls, whereas temperatures below 140 °C increased residual moisture, lowered glass transition temperature, and accelerated volatile release. These findings provide mechanistic guidance for the rational design and optimization of spray-drying processes to tailor the stability and release performance of encapsulated flavor systems.
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Inclusion complex of water-soluble arbutin with β-cyclodextrin: Computer modeling and experimental studies
(2025-03-01)
Paiboon, Narin
;
Rujipairoj, Supawan
;
Surassmo, Suvimol
;
Ruktanonchai, Uracha Rungsardthong
;
Phunpee, Sarunya
A water-soluble arbutin was investigated for its potential to form an inclusion complex with β-cyclodextrin (β-CD). Molecular modeling tests confirmed that arbutin can be accommodated within the cavity of β-CD primarily through Van der Waals forces rather than electrostatic interactions. The structure of the arbutin-β-CD inclusion complex was characterized using Differential Scanning Calorimetry (DSC), and Proton Nuclear Magnetic Resonance Spectroscopy (<sup>1</sup>H NMR). The inclusion complex prepared at a mole ratio of 1:1 (arbutin: β-CD) exhibited the highest encapsulation efficiency at 43.72 %. The study findings affirm that encapsulation of arbutin within β-CD does not reduce its inherent antioxidant activity and its inhibitory effects against tyrosinase enzyme activity. Moreover, the complexation of arbutin with β-CD resulted in a notably slower release rate, indicating the role of β-CD in modulating substance release kinetics. Furthermore, encapsulation of arbutin within β-CD demonstrated a reduction in hydrolysis from arbutin to hydroquinone by Staphylococcus epidermidis, highlighting the potential of the inclusion complex to mitigate enzymatic conversion processes.
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Synthesis of Cyclodextrin-Grafted Chitosan: From Laboratory Scale to Pilot Scale
(2023-12-15)
Paiboon, Narin
;
Phunpee, Sarunya
;
Ruktanonchai, Uracha Rungsardthong
;
Surassmo, Suvimol
;
Methaapanon, Rungthiwa
The CD-g-CS complex particle, made from the synthesis of toluenesulfonyl β-cyclodextrin (TsCD) and chitosan (CS), has a wide range of applications. Previous laboratory studies have proven the feasibility of the synthesis process, but larger-scale studies are necessary for wide utilization. This study aimed to scale up the reaction process from a 250 mL laboratory scale to 2, 10, and 500 L batch stirred-tank reactors, using a stepwise approach. Factors such as the mole ratio of TsCD to CS, reaction temperature, and reaction time were studied to optimize the synthesis. The degree of N-substitution (DS) was used to assess the number of grafted TsCD per primary amino group of chitosan, which is the key measure of the high-quality CD-g-CS. The results indicated that the DS increased with the increasing TsCD to CS mole ratio and reached a maximum at a reaction temperature of 95 °C. The reaction reached optimum results after 24 h. The constant heat transfer rate per unit volume was used as a successful scaling factor for the 10 and 500 L CD-g-CS processes.

Paiboon, Narin

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