Antimalarial and cytotoxic depsidones from the fungus Chaetomium brasiliense

Khumkomkhet, Primmala; Kanokmedhakul, Somdej; Kanokmedhakul, Kwanjai; Hahnvajanawong, Chariya; Soytong, Kasem

doi:10.1021/np9003189

Antimalarial and cytotoxic depsidones from the fungus Chaetomium brasiliense

Author(s)

Khumkomkhet, Primmala

Kanokmedhakul, Somdej

Kanokmedhakul, Kwanjai

Hahnvajanawong, Chariya

Soytong, Kasem

Date Issued

August 28, 2009

Type

Article

DOI

10.1021/np9003189

Abstract

Four new depsidones, mollicellins K-N (1-4), and six known depsidones, mollicellins B (5), C (6), E (7), F (8), H (9), and J (10), along with two known sterols were isolated from the fungus Chaetomium brasiliense. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic data and chemical transformation. Among these isolates, 1-3, 5-7, and 10 exhibited antimalarial activity against Plasmodium falciparum. Only 1 exhibited antimycobacterial activity against Mycobacterium tuberculosis and antifungal activity against Candida albicans using in vitro assays. In addition, 1-10 showed cytotoxicity against the KB, BC1, NCI-H187, and five cholangiocarcinoma cell lines. © 2009 American Chemical Society and American Society of Pharmacognosy.

Citation

Journal of Natural Products, 72(8), 1487-1491, 2009